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The probability of primitive neuroectodermal tumors to have recurrence and metastasize through cerebrospinal fluid is relatively high.<ref name=":2" /> The prognosis of PNET is 5 years of survival for less than 50% of children, <ref name=":0" /> while the most common prognosis for adults is 7 years.<ref name=":1" /> Moreover, children have the probability of developing deficiencies in cognitive processes, problems in the endocrine system, and psychological obstacles after the disease.<ref name=":1" /> Adults, on the other hand, don't show such results.<ref name=":1" /> The outcome for PNET is more positive when the individual is an adult, independent of age subgroups, or an older child.<ref name=":1" /> The reason the prognosis for such tumor is worst in children is due to the high probability of the tumor spreading to the rest of the nervous system through the cerebrospinal fluid and growing again.<ref name=":1" /> As a consequence, 37.7% of children affected by the tumor live to 4 years.<ref name=":1" />
The effect of treatment strategies such as chemotherapy and radiation therapy on the prognosis of the disease is still controversial, with studies claiming either their benefits or their ineffectiveness.<ref name=":1" /> The same holds true for the relationship between volume of tumor removed by surgery and survival.<ref name=":1" /> Furthermore, factors such as tumor size, ___location of origin, race, and sex of individual don't show any influence on the outcome of the disease.<ref name=":1" /> However, interactions of some factors such as tumor site, age, and treatment strategy can affect one's prognosis.<ref name=":1" /> For instance, when younger children below the age of 3 suffering from tumors originating in places other than the pineal gland are treated with chemotherapy, they present better outcomes than those suffering from pineal tumors.<ref name=":1" />
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