G-CSF factor stem-loop destabilising element: Difference between revisions

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The '''G-CSF factor stem-loop destabilising element (SLDE)''' is an [[cis-regulatory element|RNA element]] secreted by [[fibroblast]]s and [[endothelial cells]] in response to the inflammatory mediators [[interleukin-1]] (IL-1) and [[tumour necrosis factor-alpha]] and by activated [[macrophage]]s. The synthesis of G-CSF is regulated both [[transcription (genetics)|transcriptionally]] and through control of [[mRNA]] stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of [[monocyte]]s and macrophages, in response to [[lipopolysaccharide]]. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the [[polyadenylation|poly(A) tail]].<ref>{{cite journal | lastvauthors = Putland | first = RA, |author2=Sassinis TA|author3=, Harvey JS|author4=, Diamond P|author5=, Coles LS|author6=, Brown CY|author7=, Goodall GJ | year = 2002 | title = RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation | journal = MolMolecular Celland BiolCellular Biology | volume = 22 | issue = 6 | pages = 1664&ndash;16731664–73 | date = March 2002 | pmid = 11865046 | pmc = 135610 | doi = 10.1128/MCB.22.6.1664-1673.2002 | issue = 6 | pmc = 135610}}</ref>

== References ==

{{reflist|1}}

== External links ==

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==External links==

* {{Rfam|id=RF00183|name=G-CSF factor stem-loop destabilising element (SLDE)}}