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{{Infobox_gene}}
'''Endothelin converting enzyme 1''', also known as '''ECE1''', is an [[enzyme]] which in humans is encoded by the ''ECE1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref><ref name="pmid7805846">{{cite journal | vauthors = Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H | title = Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) | journal = FEBS Lett. | volume = 356 | issue = 2–3 | pages = 238–43 |date=December 1994 | pmid = 7805846 | doi = 10.1016/0014-5793(94)01277-6
== Function ==
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*{{cite journal | vauthors=Matsuoka R, Sawamura T, Yamada K |title=Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1 |journal=Cytogenet. Cell Genet. |volume=72 |issue= 4 |pages= 322–4 |year= 1996 |pmid= 8641140 |doi=10.1159/000134214 |display-authors=etal}}
*{{cite journal | vauthors=Orzechowski HD, Richter CM, Funke-Kaiser H |title=Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells |journal=J. Mol. Med. |volume=75 |issue= 7 |pages= 512–21 |year= 1997 |pmid= 9253714 |doi=10.1007/s001090050136 |display-authors=etal}}
*{{cite journal | vauthors=Schweizer A, Valdenaire O, Nelböck P |title=Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations |journal=Biochem. J. |volume=328 ( Pt 3) |issue= Pt 3|pages= 871–7 |year= 1998 |pmid= 9396733 |doi= 10.1042/bj3280871| pmc=1218999 |display-authors=etal}}
*{{cite journal | vauthors=Kido T, Sawamura T, Masaki T |title=The processing pathway of endothelin-1 production |journal=J. Cardiovasc. Pharmacol. |volume=31 Suppl 1 |issue= |pages= S13–5 |year= 1998 |pmid= 9595387 |doi=10.1097/00005344-199800001-00006 }}
*{{cite journal | vauthors=Hofstra RM, Valdenaire O, Arch E |title=A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction |journal=Am. J. Hum. Genet. |volume=64 |issue= 1 |pages= 304–8 |year= 1999 |pmid= 9915973 |doi=10.1086/302184 | pmc=1377732 |display-authors=etal}}
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*{{cite journal | vauthors=Eckman EA, Watson M, Marlow L |title=Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2081–4 |year= 2003 |pmid= 12464614 |doi= 10.1074/jbc.C200642200 |display-authors=etal}}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | vauthors=Masatsugu K, Itoh H, Chun TH |title=Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress |journal=Regul. Pept. |volume=111 |issue= 1–3 |pages= 13–9 |year= 2003 |pmid= 12609744 |doi=10.1016/S0167-0115(02)00219-7 |display-authors=etal|hdl=2433/147555 }}
*{{cite journal | vauthors=Smollich M, Götte M, Yip GW |title=On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer |journal=Breast Cancer Res. Treat. |volume=106 |issue= 3 |pages= 361–9 |year= 2007 |pmid= 17295044 |doi= 10.1007/s10549-007-9516-9 |display-authors=etal}}
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