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'''''Life Extension: A Practical Scientific Approach''''' is a 1982 book ({{ISBN|0-446-51229-X}}) by [[Durk Pearson]] and [[Sandy Shaw (writer)|Sandy Shaw]] that popularized the [[life extension]] and [[Nootropic|smart drug]] movements.<ref>See ''Rapture: How Biotech Became the New Religion'', by Brian S. Alexander, New York: Basic Books, 2003, {{ISBN|0-7382-0761-6}}, pp. 5–6.</ref><ref>{{cite news |first=Katherine |last=Bishop |publisher=[[Seattle Post-Intelligencer]] newspaper|title=FDA fears smart drugs could pose stupid risks |date=1992-06-11 |accessdate=2007-03-01 |url=http://docs.newsbank.com/openurl?ctx_ver=z39.88-2004&rft_id=info:sid/iw.newsbank.com:AWNB:SPIB&rft_val_format=info:ofi/fmt:kev:mtx:ctx&rft_dat=0EB04A057A2FC5B9&svc_dat=InfoWeb:aggregated4&req_dat=0D0CB57AB53DF815 }}</ref>
The bookauthors discussedpromoted the theory that [[Radical (chemistry)|free radical]]s andare thea idea that theyprimary cause of aging, and howrecommended [[antioxidant]]s were saidsupplements to partially prevent the damage they supposedly do.<ref>{{cite news| first=Dennis |last=Fiely |title='Biochemical bad boys' - Possible causes of disease, free radicals, may have met their match |publisher=Columbus Dispatch |date=1993-09-16 |accessdate=2007-03-01 |url=http://docs.newsbank.com/openurl?ctx_ver=z39.88-2004&rft_id=info:sid/iw.newsbank.com:AWNB:CLDB&rft_val_format=info:ofi/fmt:kev:mtx:ctx&rft_dat=10E0DA583AA751E0&svc_dat=InfoWeb:aggregated4&req_dat=0D0CB57AB53DF815}}</ref> The book suggestsmakes causesa broad range of agingclaims andabout ways to slowthwart them,aging withand material on improvingimprove health and various aspects of the quality of lifeappearance.
One notable feature of the book was several full-page pictures of its male and female authors, Durk Pearson and Sandy Shaw, striking bodybuilding poses and showing off some impressive muscles for "sedentary research scientists," which they claimed was due to the "growth hormone releasers" they took daily.
[[Leonard Hayflick]] deemed it "a glib, superficial overview of the field.,“ adding that he "would be very unhappy to learn that there were substantial numbers of people depending on its contents for guidance.” [[Denham Harman]], to whom the book was dedicated and whose free radical theory of aging was favored by Pearson and Shaw, opined, "I think basically the book is sound."<ref>{{cite web |author1=Karen G. Jackovich |title=Two Fitness Faddists Have a No. 1 Best-Seller, but Are They Stretching Life Spans or Truth? |url=https://people.com/archive/two-fitness-faddists-have-a-no-1-best-seller-but-are-they-stretching-life-spans-or-truth-vol-18-no-14/ |website=people.com |accessdate=8 September 2019 |date=October 4, 1982}}</ref>
[[Gerontology#Biogerontology|Biogerontologist]] [[Roy Walford]] wrote, "[[gerontology]] has always been the happy hunting ground for faddists, charlatans, pseudoscientific fringe characters, and just misinformed enthusiasts with 'ready cures' for aging. ... Pearson and Shaw are among this long list of enthusiasts. ... Most of the Pearson/Shaw book relies on this lower-order category of evidence, and upon the testimonial posturing of Pearson and Shaw themselves."<ref name=Walford>{{cite book|last=Walford|first=Roy|title=Beyond the 120 Year Diet: How to Double Your Vital Years|year=2000|publisher=Four Walls Eight Windows|___location=New York, NY|isbn= 9781568581576|pages=21–23|url=https://books.google.com/books?id=I0GeWFLLbQEC&pg=PA21&lpg=PA21}}</ref> In a discussion group posting, biogerontologist Dr. Steve Harris, MD criticizes the book, offering an example of one the authors' "screwups:"
:: I managed to track one of their references to the (supposedly) somniferous effects of inositol back through some of the primary literature they'd cited (loosely) in the back of the chapter. Wups, guess what? They'd been reading a paper on natural ligands of the benzodiazepine receptor, and confused inositol with inosine (helped out by [[Carl Pfeiffer (pharmacologist)| [Carl] Pffeifer]]'s [sic] claims that inositol is sleep inducing). Inosine actually HAS some demonstrated Valium like effects in some animals (birds), but to this day you're going to see inositol in sleep remedies.<ref name="Harris, 1995">{{cite web|last=Harris|first=Steve|title=Re: Whats up with Pearson & Shaw|url=http://groups.google.com/group/sci.life-extension/msg/3ba7eb3669464c37|accessdate=2 June 2012}}</ref>
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