Content deleted Content added
m →Mitotic Selection: clean up |
m Journal cites, Added 2 dois to journal cites |
||
Line 46:
==== Inhibition of [[Cyclin-dependent kinase 1|CDK1]] ====
CDK1 is necessary for the transition from G2 to M phase. RO-3306 is a selective CDK1 inhibitor that can reversibly arrest cells at the G2/M border. RO-3306 synchronized >95% of cycling cells (including cancer cells), and released cells rapidly enter mitosis.<ref>{{Cite journal|last=Vassilev|first=Lyubomir T|date=8 November 2006|title=Cell Cycle Synchronization at the G2/M Phase Border by Reversible Inhibition of CDK1|url=|journal=Cell Cycle|volume=5|issue=22|pages=2555–2556|via=Taylor & Francis Online|doi=10.4161/cc.5.22.3463}}</ref>
==== [[Roscovitine]] ====
Line 61:
==== [[Hydroxycarbamide|Hydroxyurea]] ====
Hydroxyurea decreases the production of [[Dideoxynucleotide|dNTPs]] by inhibiting the enzyme [[ribonucleotide reductase]]. This serves to halt DNA synthesis by depriving [[DNA polymerase]] of dNTPs at [[replication fork]]s.<ref>{{Cite journal|last=Koc|first=Ahmet|last2=Wheeler|first2=Linda J.|last3=Mathews|first3=Christopher K.|last4=Merrill|first4=Gary F.|date=21 October 2003|title=Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools|url=|journal=Journal of Biological Chemistry|volume=279|pages=223–230|via=|doi=10.1074/jbc.m303952200}}</ref> Hydroxyurea is also used to treat certain types of cancer and blood disorders.
==== [[Aphidicolin]] ====
| |||