G-CSF factor stem-loop destabilising element: Difference between revisions

Revision as of 19:11, 14 May 2019

Revision as of 20:50, 8 October 2019

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| miRBase =

| miRBase_family =

| RNA_type = [[Cis-regulatory element | Cis-reg]]

| Tax_domain = [[Eukaryota]]

| GO =

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The '''G-CSF factor stem-loop destabilising element (SLDE)''' is an [[cis-regulatory element|RNA element]] secreted by [[fibroblast]]s and [[endothelial cells]] in response to the inflammatory mediators [[interleukin-1]] (IL-1) and [[tumour necrosis factor-alpha]] and by activated [[macrophage]]s. The synthesis of G-CSF is regulated both [[transcription (genetics)|transcriptionally]] and through control of [[mRNA]] stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of [[monocyte]]s and macrophages, in response to [[lipopolysaccharide]]. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the [[polyadenylation|poly(A) tail]].<ref>{{cite journal | vauthors = Putland RA, Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ | title = RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation | journal = Molecular and Cellular Biology | volume = 22 | issue = 6 | pages = 1664–731664–1673 | date = March 2002 | pmid = 11865046 | pmc = 135610 | doi = 10.1128/MCB.22.6.1664-1673.2002 }}</ref>

== References ==

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== External links ==

* {{Rfam|id=RF00183|name=G-CSF factor stem-loop destabilising element (SLDE)}}

[[Category:Cis-regulatory RNA elements]]

{{molecular-cell-biology-stub}}