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A [[laser]] generates a [[gaussian beam]] which focuses inside a flow cell. A particle that passes through the focal region generates an interference in the beam, which is collected with a sensor. Through this signal it is possible to derive the real part and the imaginary part of the forward scattering field from each particle.
The technique was developed to measure aerosols in air<ref>{{Cite journal |doi = 10.1007/s11051-017-3995-3|title = Single Particle Extinction and Scattering allows novel optical characterization of aerosols|journal = Journal of Nanoparticle Research|volume = 19|issue = 8|pages = 291|year = 2017|last1 = Mariani|first1 = Federico|last2 = Bernardoni|first2 = Vera|last3 = Riccobono|first3 = Francesco|last4 = Vecchi|first4 = Roberta|last5 = Valli|first5 = Gianluigi|last6 = Sanvito|first6 = Tiziano|last7 = Paroli|first7 = Bruno|last8 = Pullia|first8 = Alberto|last9 = Potenza|first9 = Marco A. C.|bibcode = 2017JNR....19..291M}}</ref> and particles in liquid.<ref>{{Cite journal |title=Single particle optical extinction and scattering allows real time quantitative characterization of drug payload and degradation of polymeric nanoparticles |last=Milani |first=P. |last2=Lenardi |first2=C. |date=2015-12-15 |journal=Scientific Reports |volume=5 |pages=18228 |doi=10.1038/srep18228 |pmid=26667064 |last3=Paroli |first3=B. |last4=Cella |first4=C. |last5=Argentiere |first5=S. |last6=Sanvito |first6=T. |last7=Potenza |first7=M. a. C.|bibcode=2015NatSR...518228P |pmc=4678328 }}</ref>
== References ==
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