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The original paper that described the CANGEN<ref name="SMILES2"/> algorithm claimed to generate unique SMILES strings for graphs representing molecules, but the algorithm fails for a number of simple cases (e.g. [[cuneane]], 1,2-dicyclopropylethane) and cannot be considered a correct method for representing a graph canonically.<ref>{{cite book |publisher=Springer |___location=Berlin |isbn=978-3-540-27967-9 |volume=3615 |pages=145–157 | editor-first = Bertram | editor-last=Ludäscher | last1 = Hutchison | first1 = David | first2 = Takeo | last2 = Kanade | first3 = Josef | last3 = Kittler | first4 = Jon M. | last4 = Klienberg | author-link4 = Jon Kleinberg | first5 = Friedemann | last5 = Mattern | first6 = John C. | last6 = Mitchell | first7 = Moni | last7 = Naor | author-link7 = Moni Naor | first8 = Oscar | last8 = Nierstrasz | first9 = C. Pandu | last9 = Rangan | author-link9 = Bernhard Steffen (computer scientist) | first10 = Bernhard | last10 = Steffen | first11 = Madu | last11 = Sudan | author-link11 = Madhu Sudan | first12 = Demetri | last12 = Terzopoulos | first13 = Dough | last13 = Tygar | first14 = Moshe Y. | last14 = Vardi | author-link14 = Moshe Y. Vardi | first15 = Gerhard | last15 = Weikum | first16 = Louiqa | last16 = Raschid |author16-link=Louiqa Raschid | first17 = Greeshma | last17 = Neglur | first18 = Robert L. | last18 = Grossman | first19 = Bing | last19 = Liu | name-list-format = vanc | series = Lecture Notes in Computer Science |title=Data Integration in the Life Sciences |chapter=Assigning Unique Keys to Chemical Compounds for Data Integration: Some Interesting Counter Examples |accessdate=2013-02-12 |year=2005 |chapterurl=https://doi.org/10.1007%2F11530084_13 |doi=10.1007/11530084_13 }}</ref> There is currently no systematic comparison across commercial software to test if such flaws exist in those packages.
SMILES notation allows the specification of [[molecular configuration|configuration at tetrahedral centers]], and double bond geometry. These are structural features that cannot be specified by connectivity alone, and therefore SMILES which encode this information are termed isomeric SMILES. A notable feature of these rules is that they allow rigorous partial specification of chirality. The term isomeric SMILES is also applied to SMILES in which [[
== Graph-based definition ==
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