Substitution matrix: Difference between revisions

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== Terminology ==

Although "[[Stochastic matrix|transition matrix]]" is often used interchangeably with "substitution matrix" in fields other than bioinformatics, the former term is problematic in bioinformatics. With regards to nucleotide substitutions, "[[transition (genetics)|transition]]" is also used to indicate those substitutions that are between the two-ring [[purine]]s (A → G and G → A) or are between the one-ring [[pyrimidine]]s (C → T and T → C). Because these substitutions do not require a change in the number of rings, they occur more frequently than the other substitutions. "[[Transversion]]" is the term used to indicate the slower-rate substitutions that change a purine to a pyrimidine or vice versa (A ↔ C, A ↔ T, G ↔ C, and G ↔ T).

== See also ==