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The '''kokko and rector model''' is a theory to explain how a gradient is generated in the inner [[medulla]].
It was previously thought that the gradient was generated by the counter current mechanism (is is the case in the outer [[medulla]]). But it has been proven that this cannot be the case in the inner [[medulla]], since there are no salt pumps, and the [[cell membrane]] is too [[permeable]] to salt.
The kokko and rector model suggests that in the inner medulla the driving force for salt reabsorption is urea accumulation.
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