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===Epithelial-mesenchymal transition===
Prior to migration, during a process known as epithelial-mesenchymal transition, there is a loss of cell contact, remodelling of the [[cytoskeleton]] and increased motility and interaction with extracellular components in the matrix.<ref name= "pmid8714286" >{{cite journal |vauthors= Hay ED| title = An overview of epithelio-mesenchymal trans-formation | journal = Acta Anatomica | volume = 154 | issue = 1 | pages = 8–20| date = 1995 | pmid = 8714286 | doi=10.1159/000147748}}</ref> An important step in this process is the suppression of adhesion protein [[E-cadherin]] present on [[epithelial cells]] to initiate the migration process. This suppression mechanism occurs via the [[growth factor]] BMP signalling to turn on a transcriptional repressor Smad-interacting protein 1 (Sip1) and marks the beginning of the epithelial-mesenchymal transition.<ref name= "pmid11430829" >{{cite journal |vauthors= Comijn J,
===Early migration===
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===Pulmonary venous system===
During [[cardiogenesis]], migration of the cardiac neural crest complex occurs prior to the development of the pulmonary system. There is no visible difference in the pulmonary veins of chick embryos that developed persistent truncus arteriosus and embryos with an intact cardiac neural crest complex. Ablation of the cardiac neural crest complex do not play a role in the systemic or pulmonary venous system as no visible venous defects is observed.<ref name= "pmid2923280" >{{cite journal |vauthors= Phillips III MT, Waldo K, Kirby ML| title = Neural crest ablation does not alter pulmonary vein development in the chick embryo.
===Derivative development===
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