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Cross-platform benchmarks led to highlight the effect of glycan presentation and spacing on binding.<ref name="Cross-platform comparison of glycan microarray formats">{{cite journal |vauthors=Wang L, Cummings RD, Smith DF, Huflejt M, Campbell CT, Gildersleeve JC, Gerlach JQ, Kilcoyne M, Joshi L, Serna S, Reichardt NC, Parera Pera N, Pieters RJ, Eng W, Mahal LK|title=Cross-platform comparison of glycan microarray formats|journal= Glycobiology |date= Jun 2014|volume=24|issue=6|pages=507–17|doi=10.1093/glycob/cwu019|pmid= 24658466 |pmc=4001710}}</ref>
Glycan arrays are possibly combined with other techniques such as [[Surface Plasmon Resonance]] (SPR) to refine the characterisation of [[Glycan-protein interactions|glycan-binding]]. For example, this combination led to demonstrate the calcium-dependent heparin binding of [[Annexin A1]] that is involved in several biological processes including [[inflammation]], [[apoptosis]] and [[membrane trafficking]].<ref name="Characterization of annexin A1 glycan binding reveals binding to highly sulfated glycans with preference for highly sulfated heparan sulfate and heparin">{{cite journal |vauthors=Horlacher T, Noti C, de Paz JL, Bindschädler P, Hecht ML, Smith DF, Fukuda MN, Seeberger PH|title=Characterization of annexin A1 glycan binding reveals binding to highly sulfated glycans with preference for highly sulfated heparan sulfate and heparin|journal=Biochemistry|date=Apr 2011|volume=50|issue=13|pages=2650–9|doi=10.1021/bi101121a|pmid= 21370880 |pmc=3068229}}</ref>
==References==
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