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The main sources of CSDB data are:
* Scientific publications indexed in the dedicated citation databases, including [https://www.ncbi.nlm.nih.gov/pubmed/ NCBI Pubmed] and [http://webofknowledge.com/ Thomson Reuters Web Of Science] (approx. 18000 records).
* CCSD (Carbbank <ref>{{cite journal|author=Doubet S.|author2=Albersheim P.| date=1992|journal=Glycobiology|volume=2|issue=6 |pages=505–507 |title=CarbBank|pmid=1472756|doi=10.1093/glycob/2.6.505|doi-access=free}}</ref>) database (approx. 3000 records).
The data are selected and added to CSDB manually by browsing original scientific publications. The data originating from other databases are subject to error-correction and approval procedures.<ref name="Critical">{{cite journal| author=Egorova K.S.| author2=Toukach Ph.V.| date=2012|journal=Journal of Chemical Information and Modeling |volume=52|pages=2812–2814 |title=Critical analysis of CCSD data quality| issue=11|doi=10.1021/ci3002815|pmid=23025661}}</ref>
As of 2017, the coverage on [[bacteria]] and [[archaea]] is ca. 80% of carbohydrate structures published in scientific literature <ref name="Merged_CSDB"/> The time lag between the publication of relative data and their deposition into CSDB is about 18 months. Plants are covered up to 1997, and fungi up to 2012.<ref name="PFCSDB">{{cite journal| author=Egorova K.S.| author2=Toukach Ph.V.| date=2013|journal=Carbohydrate Research |volume=389|pages=112–114|title=Expansion of coverage of Carbohydrate Structure Database (CSDB)|doi=10.1016/j.carres.2013.10.009|pmid=24680503}}</ref>
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