Lymphoid neoplasms with plasmablastic differentiation: Difference between revisions

Revision as of 12:53, 29 June 2020

Revision as of 09:07, 30 June 2020

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*'''2)''' [[Epstein-Barr virus-associated lymphoproliferative diseases#Epstein–Barr virus-associated plasma cell|Plasmablastic plasma cell lymphoma]] or [[Epstein-Barr virus-associated lymphoproliferative diseases#Epstein–Barr virus-associated plasma cell|plasmablastic plasmacytoma]]: A lymphoid neoplasm that disseminates widely like the plasma cell lesions in [[multiple myeloma]] or is localized like the plasma cell lesions in [[plasmacytoma]].

*'''3)''' [[Primary effusion lymphoma|Primary effusion lymphoma, human herpes virus-positive]]: Also termed primary effusion lymphoma, type I; it is usually characterized by manifesting [[effusion]]s in body cavities.

*'''4)''' [[Primary effusion lymphoma#KSHV/HHV8-negative primary effusion lymphoma​lymphoma|Primary effusion lymphoma, human herpes virus-negative]]: Also termed primary effusion lymphoma, type II; it is characterized by having effusions in body cavities.

*'''5)''' [[ALK+ large B-cell lymphoma|Anaplastic lymphoma kinase-positive large B-cell lymphoma]]: An [[anaplastic large cell lymphoma]] in which the malignant cells have plasmablastic features and a distinguishing [[mutation]] in the ''[[anaplastic lymphoma kinase]]'' gene.

*'''6)''' [[Diffuse large B-cell lymphoma#Epstein–Barr virus-positive diffuse large B-cell lymphoma, not otherwise specified​specified|Human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified]]: This lymphoid neoplasm usually arises from the lymphoproliferative disease, [[idiopathic]] [[Castleman disease#Human herpesvirus 8 associated multicentric Castleman disease|multicentric Castleman disease]].

Except for human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified, these lymphoid neoplasms are often associated with [[Epstein-Barr virus]] infection of the malignant plasmablastic cells. In cases so infected, the lymphoid neoplasm may result, at least in part, from this viral infection and therefore can be considered as examples of the [[Epstein-Barr virus-associated lymphoproliferative diseases#EBV+ B cell lymphoproliferative diseases|Epstein-Barr virus-associated lymphoproliferative diseases]].<ref name="pmid31725418"/>