Memory tends to begin to fade as when enter and go through adulthood. Ane-Victoria Idland et al.,<ref name=":0">{{Cite journal|last=Idland|first=Ane-Victoria|last2=Sala-Llonch|first2=Roser|last3=Watne|first3=Leiv Otto|last4=Brækhus|first4=Anne|last5=Hansson|first5=Oskar|last6=Blennow|first6=Kaj|last7=Zetterberg|first7=Henrik|last8=Sørensen|first8=Øystein|last9=Walhovd|first9=Kristine Beate|last10=Wyller|first10=Torgeir Bruun|last11=Fjell|first11=Anders Martin|date=September 2020|title=Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults|url=https://linkinghub.elsevier.com/retrieve/pii/S0197458020301214|journal=Neurobiology of Aging|language=en|volume=93|pages=1–15|doi=10.1016/j.neurobiolaging.2020.04.002}}</ref> investigated the biological factors that begin to form in a person’s older life and examined biological markers that could help explain the decrease in memory. TheseThey markersfocused includedon “betabeta amyloid 1–42 (Aβ42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL).”,<ref name=":0" /> wereand thetheir primaryfindings focussuggest ofthat tauopathy and FABP3 tended to be associated with the studymost memory decline. TheirfindingsAs concludeindividuals thatage, certainthe individualshippocampus withappears certainto markersbegin to arelose moreits likelyability to suffermake fromconnections to life events and memory.<ref>{{Cite problemsjournal|last=Dahan|first=Lionel|last2=Rampon|first2=Claire|last3=Florian|first3=Cédrick|date=August 2020|title=Age-related memory decline, dysfunction of the hippocampus and therapeutic opportunities|url=https://linkinghub.elsevier.com/retrieve/pii/S0278584620302591|journal=Progress in Neuro-Psychopharmacology and Biological Psychiatry|language=en|volume=102|pages=109943|doi=10.1016/j.pnpbp.2020.109943}}</ref>
Time is also believed to be a factor in the eventual decline of memory within adults. With increased years certain degradation of brain functions and areas begin to take its toll. The hippocampus appears to begin to lose its ability to make connections to life events and memory.<ref>{{Cite journal|last=Dahan|first=Lionel|last2=Rampon|first2=Claire|last3=Florian|first3=Cédrick|date=August 2020|title=Age-related memory decline, dysfunction of the hippocampus and therapeutic opportunities|url=https://linkinghub.elsevier.com/retrieve/pii/S0278584620302591|journal=Progress in Neuro-Psychopharmacology and Biological Psychiatry|language=en|volume=102|pages=109943|doi=10.1016/j.pnpbp.2020.109943}}</ref>
