Modulibacteria: Difference between revisions

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'''Modulibacteria''' is a [[Bacterial phyla|bacterial phylum]] formerly known as KS3B3 or GN06. It is a [[Candidatus|candidate]] phylum, meaning there are no cultured representatives of this group. Members of the Modulibacteria phylum are known to cause fatal filament overgrowth (bulking) in high-rate industrial anaerobic wastewater treatment bioreactors.<ref>{{Cite journal|last1=Yamada|first1=Takeshi|last2=Yamauchi|first2=Toshihiro|last3=Shiraishi|first3=Koji|last4=Hugenholtz|first4=Philip|last5=Ohashi|first5=Akiyoshi|last6=Harada|first6=Hideki|last7=Kamagata|first7=Yoichi|last8=Nakamura|first8=Kazunori|last9=Sekiguchi|first9=Yuji|date=2007-05-31|title=Characterization of filamentous bacteria, belonging to candidate phylum KSB3, that are associated with bulking in methanogenic granular sludges|journal=The ISME Journal|volume=1|issue=3|pages=246–255|doi=10.1038/ismej.2007.28|pmid=18043635|issn=1751-7362}}</ref><ref>{{Cite journal|last1=Yamada|first1=Takeshi|last2=Kikuchi|first2=Kae|last3=Yamauchi|first3=Toshihiro|last4=Shiraishi|first4=Koji|last5=Ito|first5=Tsukasa|last6=Okabe|first6=Satoshi|last7=Hiraishi|first7=Akira|last8=Ohashi|first8=Akiyoshi|last9=Harada|first9=Hideki|last10=Kamagata|first10=Yoichi|last11=Nakamura|first11=Kazunori|date=2011-01-21|title=Ecophysiology of Uncultured Filamentous Anaerobes Belonging to the Phylum KSB3 That Cause Bulking in Methanogenic Granular Sludge|journal=Applied and Environmental Microbiology|volume=77|issue=6|pages=2081–2087|doi=10.1128/aem.02475-10|pmid=21257808|pmc=3067334|issn=0099-2240}}</ref>.

The Modulibacteria phylum was first proposed in 2006 by two independent research groups based on analyses of 16S rRNA gene sequences. One group recovered Modulibacteria sequences from the a hypersaline microbial mat from Guerrero Negro (Baja California Sur, Mexico) and used the provisional name GN06 for the novel phylum,<ref>{{Cite journal|last1=Ley|first1=Ruth E.|last2=Harris|first2=J. Kirk|last3=Wilcox|first3=Joshua|last4=Spear|first4=John R.|last5=Miller|first5=Scott R.|last6=Bebout|first6=Brad M.|last7=Maresca|first7=Julia A.|last8=Bryant|first8=Donald A.|last9=Sogin|first9=Mitchell L.|last10=Pace|first10=Norman R.|date=2006-05-01|title=Unexpected Diversity and Complexity of the Guerrero Negro Hypersaline Microbial Mat|journal=Applied and Environmental Microbiology|language=en|volume=72|issue=5|pages=3685–3695|doi=10.1128/AEM.72.5.3685-3695.2006|issn=0099-2240|pmid=16672518|pmc=1472358}}</ref>, while the other recovered sequences from sulfur-rich black mud marine sediments (CA, USA) and used the provisional name KSB3.<ref>{{Cite journal|last=Tanner|first=Michael|date=2006|title=Complex Microbial Communities Inhabiting Sulfide-rich Black Mud from Marine Coastal Environments|journal=Biotechnology et Alia|volume=8|pages=1–16}}</ref>.

The first genomic insights into the phylum were achieved in 2015, at which time the name "Modulibacteria" was proposed.<ref name=":0" />. Two genomes were recovered from methanogenic sludge samples of a full-scale upflow anaerobic sludge blanket (UASB) reactor treating a high-strength organic wastewater discharged from a food-processing factory. Through a combination of genome-based metabolic reconstruction and microscopic observation, it was determined that the two studied Modulibacteria species (''Moduliflexus flocculans'' and ''Vecturithrix granuli'') produce filamentous structures and are Gram-negative, strictly anaerobic fermenters capable of non-flagellar based gliding motility. Both have an unusually large number of sensory and response regulator genes compared to other bacteria.<ref name=":0" />.

Members of the Modulibacteria phylum have been detected in a variety of environments in addition to bioreactors and hypersaline mats, such as wetland sediments ([https://www.ncbi.nlm.nih.gov/nuccore/FJ516883 FJ516883.1]), the dolphin mouth,<ref>{{Cite journal|last1=Bik|first1=Elisabeth M.|last2=Costello|first2=Elizabeth K.|last3=Switzer|first3=Alexandra D.|last4=Callahan|first4=Benjamin J.|last5=Holmes|first5=Susan P.|last6=Wells|first6=Randall S.|last7=Carlin|first7=Kevin P.|last8=Jensen|first8=Eric D.|last9=Venn-Watson|first9=Stephanie|last10=Relman|first10=David A.|date=2016-02-03|title=Marine mammals harbor unique microbiotas shaped by and yet distinct from the sea|journal=Nature Communications|language=en|volume=7|issue=1|page=10516|doi=10.1038/ncomms10516|pmid=26839246|pmc=4742810|bibcode=2016NatCo...710516B|issn=2041-1723}}</ref><ref>{{Cite journal|last1=Dudek|first1=Natasha K.|last2=Sun|first2=Christine L.|last3=Burstein|first3=David|last4=Kantor|first4=Rose S.|last5=Aliaga Goltsman|first5=Daniela S.|last6=Bik|first6=Elisabeth M.|last7=Thomas|first7=Brian C.|last8=Banfield|first8=Jillian F.|last9=Relman|first9=David A.|date=2017-12-18|title=Novel Microbial Diversity and Functional Potential in the Marine Mammal Oral Microbiome|journal=Current Biology: CB|volume=27|issue=24|pages=3752–3762.e6|doi=10.1016/j.cub.2017.10.040|issn=1879-0445|pmid=29153320|doi-access=free}}</ref>, and a tubeworm from a coldseep ([https://www.ncbi.nlm.nih.gov/nuccore/FM165273 FM165273]).

== Taxonomy ==

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[[Category:Bacteria phyla]]