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[[Alkylation]] is one form of regulation of the coding region.<ref>{{cite journal | vauthors = Shinohara K, Sasaki S, Minoshima M, Bando T, Sugiyama H | title = Alkylation of template strand of coding region causes effective gene silencing | journal = Nucleic Acids Research | volume = 34 | issue = 4 | pages = 1189–95 | date = 2006-02-13 | pmid = 16500890 | pmc = 1383623 | doi = 10.1093/nar/gkl005 }}</ref> The gene that would have been transcribed can be silenced by targeting a specific sequence. The bases in this sequence would be blocked using [[Alkyl|alkyl groups]], which create the [[Gene silencing|silencing]] effect.<ref>{{Cite web|url=http://www.informatics.jax.org/vocab/gene_ontology/GO:0006305|title=DNA alkylation Gene Ontology Term (GO:0006305)|website=www.informatics.jax.org|access-date=2019-10-30}}</ref>
While the [[regulation of gene expression]] manages the abundance of RNA or protein made in a cell, the regulation of these mechanisms can be controlled by a [[regulatory sequence]] found before the [[open reading frame]] begins in a strand of DNA. The [[regulatory sequence]] will then determine the ___location and time that expression will occur for a protein coding region.<ref>{{Cite journal |last1=Shafee|first1=Thomas|last2=Lowe|first2=Rohan | name-list-
[[RNA splicing]] ultimately determines what part of the sequence becomes translated and expressed, and this process involves cutting out introns and putting together exons. Where the RNA [[spliceosome]] cuts, however, is guided by the recognition of [[splice site]]s, in particular the 5' splicing site, which is one of the substrates for the first step in splicing.<ref>{{cite journal | vauthors = Konarska MM | title = Recognition of the 5' splice site by the spliceosome | journal = Acta Biochimica Polonica | volume = 45 | issue = 4 | pages = 869–81 | date = 1998 | pmid = 10397335 | doi = 10.18388/abp.1998_4346 | doi-access = free }}</ref> The coding regions are within the exons, which become covalently joined together to form the [[mature messenger RNA]].
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