X-linked dominant inheritance: Difference between revisions

Revision as of 07:59, 3 September 2006

Revision as of 21:22, 6 January 2007

Line 1:

'''X-linked dominant''' is mode of [[mendelian inheritance|inheritance]] in which a [[gene]] on the [[X chromosome]] is [[dominant]]<ref>[http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/genetics/xdomin.html X-linked Dominant: Incontinentia pigmenti - Lucile Packard Children's Hospital]</ref>. Females are more frequently affected than males, althoughsince anythey have two X-linked dominantchromosomes that could potentially carry the abnormal gene, whereas isa notmale [[sexhas linkage|sexonly linked]]one. The chance of passing on an X-linked dominant disorder differs between men and women.

This inheritance pattern is less common than [[X-linked recessive]].

== Inheritance ==

Females usually have two X chromosomes, while most males have one X and one [[Y chromosome]]. If a child has inherited the mutation from the X chromosome of one of their parents they will have the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected daughter or son with each [[pregnancy]]. The sons of a man with an X-linked dominant disorder will not be affected (since they inherit their only X chromomsome from their mother), but his daughters will all inherit the condition.

<gallery>