Human Protein Reference Database: Difference between revisions

Revision as of 18:08, 22 October 2020

Revision as of 07:49, 13 December 2020

Line 6:

The HPRD is a result of an international collaborative effort between the Institute of Bioinformatics in Bangalore, India and the Pandey lab at [[Johns Hopkins University]] in Baltimore, USA. HPRD contains manually curated scientific information pertaining to the biology of most human proteins. Information regarding proteins involved in human diseases is annotated and linked to Online Mendelian Inheritance in Man (OMIM) database. The National Center for Biotechnology Information provides link to HPRD through its human protein databases (e.g. Entrez Gene, RefSeq protein pertaining to genes and proteins.

This resource depicts information on human protein functions including [[protein–protein interactions]], [[post-translational modifications]], enzyme-substrate relationships and disease associations. Protein annotation information that is catalogued was derived through manual curation using published literature by expert biologists and through bioinformatics analyses of the protein sequence. The protein–protein interaction and subcellular localization data from HPRD have been used to develop a human protein interaction network.<ref>{{cite journal | author = Gandhi T.K.B. | title = Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets | url = | journal = Nature Genetics | volume = 38| issue = 3| pages = 285–293 | doi=10.1038/ng1747 | pmid=16501559 | date=March 2006| s2cid = 1446423 |display-authors=etal}}</ref>

Highlights of HPRD as follows:

Line 20:

==PhosphoMotif Finder==

PhosphoMotif Finder<ref>{{cite journal | author = Amanchy R. | year = 2007| title = A compendium of curated phosphorylation-based substrate and binding motifs | url = | journal = Nature Biotechnology | volume = 2007 | issue = 25| pages = 285–286 | doi=10.1038/nbt0307-285| pmid = 17344875| s2cid = 38824337|display-authors=etal}}</ref> contains known kinase/phosphatase substrate as well as binding motifs that are curated from the published literature. It reports the PRESENCE of any literature-derived motif in the query sequence. PhosphoMotif Finder does NOT PREDICT any motifs in the query protein sequence using any algorithm or other computational strategies.

== Comparison of protein data ==