Endothelin converting enzyme 1: Difference between revisions

Revision as of 13:59, 3 July 2020

Revision as of 00:42, 14 December 2020

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{{Infobox_gene}}

'''<span lang="fr" dir="ltr">Endothelin</span> converting enzyme 1''', also known as '''ECE1''', is an [[enzyme]] which in humans is encoded by the ''ECE1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref><ref name="pmid7805846">{{cite journal | vauthors = Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H | title = Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) | journal = FEBS Lett. | volume = 356 | issue = 2–3 | pages = 238–43 |date=December 1994 | pmid = 7805846 | doi = 10.1016/0014-5793(94)01277-6}}</ref><ref name="pmid7864876">{{cite journal | vauthors = Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K | title = Cloning and functional expression of human endothelin-converting enzyme cDNA | journal = Biochem. Biophys. Res. Commun. | volume = 207 | issue = 2 | pages = 807–12 |date=February 1995 | pmid = 7864876 | doi = 10.1006/bbrc.1995.1258 | url = }}</ref>

== Function ==

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*{{cite journal | vauthors=Orzechowski HD, Richter CM, Funke-Kaiser H |title=Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells |journal=J. Mol. Med. |volume=75 |issue= 7 |pages= 512–21 |year= 1997 |pmid= 9253714 |doi=10.1007/s001090050136 |display-authors=etal}}

*{{cite journal | vauthors=Schweizer A, Valdenaire O, Nelböck P |title=Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations |journal=Biochem. J. |volume=328 |issue= Pt 3|pages= 871–7 |year= 1998 |pmid= 9396733 |doi= 10.1042/bj3280871| pmc=1218999 |display-authors=etal}}

*{{cite journal | vauthors=Kido T, Sawamura T, Masaki T |title=The processing pathway of endothelin-1 production |journal=J. Cardiovasc. Pharmacol. |volume=31 Suppl 1 |issue= |pages= S13–5 |year= 1998 |pmid= 9595387 |doi=10.1097/00005344-199800001-00006 }}

*{{cite journal | vauthors=Hofstra RM, Valdenaire O, Arch E |title=A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction |journal=Am. J. Hum. Genet. |volume=64 |issue= 1 |pages= 304–8 |year= 1999 |pmid= 9915973 |doi=10.1086/302184 | pmc=1377732 |display-authors=etal}}

*{{cite journal | vauthors=Lee S, Lin M, Mele A |title=Proteolytic processing of big endothelin-3 by the kell blood group protein |journal=Blood |volume=94 |issue= 4 |pages= 1440–50 |year= 1999 |pmid= 10438732 |doi= 10.1182/blood.V94.4.1440|display-authors=etal}}