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* [[Uncertainty quantification]]: Characterize the uncertainty present in a computer simulation arising from unknowns during the computer simulation's construction.
* [[Inverse problem]]s: Discover the underlying properties of the system from the physical data.
* '''Bias correction''': Use physical data to correct for bias in the simulation.
* [[Data assimilation]]: Combine multiple simulations and physical data sources into a complete predictive model.
* [[Systems design]]: Find inputs that result in optimal system performance measures.