Introduction to genetics: Difference between revisions

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Now imagine that this woman grows up and has children with a brown-haired man who also has a Bb genotype. Her eggs will be a mixture of two types, one sort containing the B allele, and one sort the b allele. Similarly, her partner will produce a mix of two types of sperm containing one or the other of these two alleles. When the transmitted genes are joined up in their offspring, these children have a chance of getting either brown or red hair, since they could get a genotype of BB = brown hair, Bb = brown hair or bb = red hair. In this generation, there is, therefore, a chance of the recessive allele showing itself in the phenotype of the children—some of them may have red hair like their grandfather.<ref name=OMIM/>

Many traits are inherited in a more complicated way than the example above. This can happen when there are several genes involved, each contributing a small part to the end result. Tall people tend to have tall children because their children get a package of many alleles that each contribute a bit to how much they grow. However, there are not clear groups of "short people" and "tall people", like there are groups of people with brown or red hair. This is because of the large number of genes involved; this makes the trait very variable and people are of many different heights.<ref>[http://www.childrensnyp.org/mschony/P02134.html Multifactorial Inheritance] Health Library, Morgan Stanley Children's Hospital, Accessed 20 May 2008</ref> Despite a common misconception, the green/blue eye traits are also inherited in this complex inheritance model.<ref name=Athro>[http://www.athro.com/evo/gen/inherit1.html#uncertainty Eye color is more complex than two genes], Athro Limited, Accessed 27 November 2010</ref> Inheritance can also be complicated when the trait depends on the interaction between genetics and environment. For example, malnutrition does not change traits like eye color, but can stunt growth.<ref>{{cite web |url=http://www.med.umich.edu/opm/newspage/2003/kidheight.htm |title=Low income kids' height doesn't measure up by age 1 |publisher=University of Michigan Health System |accessdateaccess-date=May 20, 2008 |url-status=dead |archiveurlarchive-url=https://web.archive.org/web/20080526034018/http://www.med.umich.edu/opm/newspage/2003/kidheight.htm |archivedatearchive-date=26 May 2008 |df=dmy-all }}</ref>

==How genes work==

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===Genes make proteins===

{{main|Genetic code}}

The function of genes is to provide the information needed to make molecules called [[protein]]s in cells.<ref name=Utah>{{Cite book| title =University of Utah Genetics Learning Center animated tour of the basics of genetics| publisher =Howstuffworks.com| url =http://learn.genetics.utah.edu/units/basics/tour| accessdateaccess-date =2008-01-24| url-status =dead| archiveurlarchive-url =https://web.archive.org/web/20080210023634/http://learn.genetics.utah.edu/units/basics/tour/| archivedatearchive-date =10 February 2008| df =dmy-all}}</ref> Cells are the smallest independent parts of organisms: the human body contains about 100 trillion cells, while very small organisms like [[bacteria]] are just a single cell. A cell is like a miniature and very complex factory that can make all the parts needed to produce a copy of itself, which happens when cells [[cell division|divide]]. There is a simple division of labor in cells—genes give instructions and proteins carry out these instructions, tasks like building a new copy of a cell, or repairing the damage.<ref name=NIGMS>[http://publications.nigms.nih.gov/structlife/chapter1.html The Structures of Life] National Institute of General Medical Sciences, Accessed 20 May 2008</ref> Each type of protein is a specialist that only does one job, so if a cell needs to do something new, it must make a new protein to do this job. Similarly, if a cell needs to do something faster or slower than before, it makes more or less of the protein responsible. Genes tell cells what to do by telling them which proteins to make and in what amounts.

[[File:Genetic code.svg|thumb|right|280px|Genes are expressed by being [[transcription (genetics)|transcribed]] into RNA, and this RNA then [[protein biosynthesis|translated]] into protein.]]

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[[File:PCWmice1.jpg|thumb|right|[[Mouse|Mice]] with different coat colors]]

A population of organisms evolves when an inherited trait becomes more common or less common over time.<ref name=Marshall>{{Cite book|first = Marshall| last= Brain | contribution =How Evolution Works | contribution-url =http://science.howstuffworks.com/evolution.htm/printable | title =How Stuff Works: Evolution Library| publisher =Howstuffworks.com | url =http://science.howstuffworks.com/evolution-channel.htm|accessdateaccess-date=2008-01-24 }}</ref> For instance, all the mice living on an island would be a single population of mice: some with white fur, some gray. If over generations, white mice became more frequent and gray mice less frequent, then the color of the fur in this population of mice would be [[evolving]]. In terms of genetics, this is called an increase in [[allele frequency]].

Alleles become more or less common either by chance in a process called [[genetic drift]] or by [[natural selection]].<ref>[http://evolution.berkeley.edu/evosite/evo101/IIIMechanisms.shtml Mechanisms: The Processes of Evolution] {{webarchive|url=https://web.archive.org/web/20080527163721/http://evolution.berkeley.edu/evosite/evo101/IIIMechanisms.shtml |date=27 May 2008 }} Understanding Evolution, Accessed 20 May 2008</ref> In natural selection, if an allele makes it more likely for an organism to survive and reproduce, then over time this allele becomes more common. But if an allele is harmful, natural selection makes it less common. In the above example, if the island were getting colder each year and snow became present for much of the time, then the allele for white fur would favor survival since predators would be less likely to see them against the snow, and more likely to see the gray mice. Over time white mice would become more and more frequent, while gray mice less and less.

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Since traits come from the genes in a cell, putting a new piece of DNA into a cell can produce a new trait. This is how [[genetic engineering]] works. For example, rice can be given genes from a maize and a soil bacteria so the rice produces [[beta-carotene]], which the body converts to Vitamin A.<ref>Staff [http://www.goldenrice.org/ Golden Rice Project] Retrieved 5 November 2012</ref> This can help children suffering from Vitamin A deficiency. Another gene being put into some crops comes from the bacterium ''[[Bacillus thuringiensis]]''; the gene makes a protein that is an [[insecticide]]. The insecticide kills insects that eat the plants but is harmless to people.<ref>[http://ars.usda.gov/is/ar/archive/nov99/pest1199.htm Tifton, Georgia: A Peanut Pest Showdown] USDA, accessed 16 May 2008</ref> In these plants, the new genes are put into the plant before it is grown, so the genes are in every part of the plant, including its seeds.<ref>[http://www.gmo-safety.eu/basic-info/129.bacterial-arsenal-combat-chewing-insects.html Genetic engineering: Bacterial arsenal to combat chewing insects] {{Webarchive|url=https://web.archive.org/web/20110515134013/http://www.gmo-safety.eu/basic-info/129.bacterial-arsenal-combat-chewing-insects.html |date=15 May 2011 }} GMO Safety, Jul 2010</ref> The plant's offspring inherit the new genes, which has led to concern about the spread of new traits into wild plants.<ref>[http://www.geo-pie.cornell.edu/gmo.html Genetically engineered organisms public issues education] Cornell University, Accessed 16 May 2008</ref>

The kind of technology used in genetic engineering is also being developed to treat people with [[genetic disorder]]s in an experimental medical technique called [[gene therapy]].<ref>{{cite web| last = Staff|date= November 18, 2005| url = http://www.ornl.gov/sci/techresources/Human_Genome/medicine/genetherapy.shtml| title = Gene Therapy| format = FAQ| work = Human Genome Project Information| publisher = [[Oak Ridge National Laboratory]]| accessdateaccess-date = 2006-05-28}}</ref> However, here the new, properly working gene is put in targeted cells, not altering the chance of future children inheriting the disease causing alleles.

==See also==