Indication can refer to:
- A synonym for Sign
- Human interface Highlighting the single object pointed to as a cursor is moved, without any other user action such as clicking, is indication.
- A medical term describing a valid reason to use a certain test, medication, procedure, or surgery. In the United States, indications for medications are strictly regulated by the Food and Drug Administration, which includes them in the package insert under the phrase "Indications and Usage". The opposite of indication is contraindication.