Wikipedia:WikiProject Molecular Biology/Cell Signaling

Some Wikipedians have formed a project to better organize information in articles related to Cell Signaling. This page and its subpages contain their suggestions; it is hoped that this project will help to focus the efforts of other Wikipedians. If you would like to help, please inquire on the talk page and see the to-do list there.

For more information on WikiProjects, please see Wikipedia:WikiProject and Wikipedia:WikiProject/Best practices.

Title

WikiProject on Cell Signaling

Scope

This project is dedicated to improving and organising the Wikipedia articles on cell signaling to provide a convinient and reliable reference of the known signal transduction pathways. It covers the pathway pages and individual protein pages related to them.

Goals

• Creating comprehensive articles for each known cell signaling pathway
• Organising cell signaling articles with navigation boxes like these: Wikipedia:WikiProject Molecular and Cellular Biology#Protein topics navigation boxes.
• Organising and creating articles on notable proteins involved in signaling pathways.
• Providing each pathway with a clear diagram of its structure.
• Clearly citing sources, especially for active research topics

Target audience

• Introduction to pathway articles should be make minimal use of jargon and be kept relatively simple
• Subsections and protein pages can be more technical

Parentage

This is a daughter project of WikiProject Molecular and Cellular Biology

Similar WikiProjects

WikiProject Clinical medicine and WikiProject Drugs may be relevant to this project.

Participants

Name	Talk page	Special interests
Peter Znamenskiy	Talk	Cell culture and adult stem cells
Rockpocket	Talk	G-protein coupled receptors

Structure

Proposed structure of a pathway article:

• General introduction - keep it simple and clear
• Function - the role of the pathway
• Relevance to human disease - alternatively this can be incorporated into Function
• Mechanism - the proteins involved and how they interact.
• History - discovery, seminal papers
• Current research - recent advances, future directions

Please comment!

For individual proteins, see suggestions in Wikipedia:WikiProject_Molecular_and_Cellular_Biology#Structures

Hierarchy definition

No classification of this project has been defined.

Projects

Tasks

• Resolve the Cell signaling/Signal transduction merger
• Compile list of existing cell signaling articles

Adopt an article

Similar to the Collaboration of the week, but on a smaller scale, you might want to "adopt" an article. This would involve doing the research, writing, and picture-taking (if possible) for either a non-existent article or a stub. Of course, everyone else can still edit an adopted article, and you can work on other things too, but the idea is to find a focus for a while, to try and build up the number of quality articles the Project has produced.

• Example article: User:Example

General strategy and discussion forums

• /General
• /Strategy

Templates

Infoboxes

Other templates

{{Template:Cell_signaling}}

Cell signaling / Signal transduction
Signaling pathways	GPCR Wnt RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors
Agents	Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones Cytokines Growth factors Signaling molecules Receptors Cell surface Intracellular Co-receptor Second messenger cAMP-dependent pathway Ca2+ signaling Lipid signaling Assistants: Signal transducing adaptor protein Scaffold protein Transcription factors General Transcription preinitiation complex TFIID TFIIH
By distance	Juxtacrine Autocrine / Paracrine Endocrine
Other concepts	Intracrine action Neurocrine signaling Synaptic transmission Chemical synapse Neuroendocrine signaling Exocrine signalling Pheromones Mechanotransduction Phototransduction Ion channel gating Gap junction

Categories

• Category:Signal transduction

Lists

Articles

• Signal transduction/Cell signaling

Ligand (biochemistry)

Receptor (biochemistry)

Second messenger

Protein kinase

Transcription factor

• Apoptosis

Bcl-2

Caspase

• Cell cycle
• Cell division
• Cellular differentiation
• Cell proliferation

• Calcium signaling

Calmodulin

• Cytokine
• Integrin
• Lipid signaling

Diacylglycerol

Inositol triphosphate

Inositol triphosphate receptor

Phospholipase

• JAK-STAT pathway

STAT protein

JAK

• Mammalian target of rapamycin
• MAPK/ERK pathway

Epidermal growth factor receptor

Ras

Mitogen-activated protein kinase

• NF-kB
• Notch signaling
• p53
• Transforming growth factor
• Sonic hedgehog
• Wnt signaling pathway

Catenin

GSK-3

Archives

• #1

Sister Project links

Wikimedia Commons has media related to Cell Signaling.   Wikimedia Commons has media related to Cell Signaling.   Wikiquote has quotations related to WikiProject Molecular Biology/Cell Signaling.   Look up cell signaling in Wiktionary, the free dictionary.   Wikinews has related news: Cell Signaling   Wikinews has news related to: Cell Signaling

Wikibooks has more on the topic of: WikiProject Molecular Biology/Cell Signaling   English Wikisource has original text related to this article: WikiProject Molecular Biology/Cell Signaling   Wikispecies has information related to Cell Signaling .   Meta has related information at: Cell Signaling