Sastrowardoyo is a surname, and may refer to:
- Suryono Sastrowardoyo (1920-2000) - Indonesian diplomat who served in Singapore, Italy and Poland
- Sumarsono Sastrowardoyo (b. 1922) - Indonesian physician, urologist and memoirist, author of Kembali ke Uteran; father of Marina Joesoef and paternal grandfather of Dian Sastrowardoyo
- Subagio Sastrowardoyo (1924-1995) - Indonesian poet, literary critic and essayist
- Sanyoto Sastrowardoyo (b. 1936)[1] - former Indonesian state minister for investment and chairman of the Investment Coordination Board (BPKM)[2]
- Aswin W. Sastrowardoyo - Indonesian physician; formerly guitarist and vocalist with the music group Chaseiro from 1979 to 1983[3]
- Marina Joesoef (b. 1959) - Indonesian artist sometimes referred to as Marina Joesoef Sastrowardoyo
- Rahadyan Sastrowardoyo (b. 1963) - American dilettante of Indonesian and Filipino ancestry
- Hartriono B. Sastrowardoyo (b. 1969) - American journalist of Indonesian and Filipino ancestry
- Dian Sastrowardoyo (b. 1982) - Indonesian model and actress
The surname is derived from sastra (Sanskrit, writings) and wardaya (Sanskrit, heart), so it literally means "writings of the heart."