X-linked dominant inheritance

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As a disease inheritance pattern, it is less common than X-linked recessive.

Inheritance

Females usually have two X chromosomes, while most males have one X and one Y chromosome. If a child has inherited the mutation from the X chromosome of one of their parents they will have the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected daughter or son with each pregnancy. The sons of a man with an X-linked dominant disorder will not be affected (since they inherit their only X chromosome from their mother), but his daughters will all inherit the condition.

Some X-linked dominant conditions such as Aicardi Syndrome are fatal to boys, therefore only girls with these conditions survive. Similarly, individuals with Klinefelter's Syndrome are referred to as "47,XXY Males".

See also

References