Utente:Vale maio/Sandbox5

DISCLAIMER

Questa è una sottopagina personale dove lavoro alla stesura di nuove voci o alla modifica di voci già esistenti.
Gentilmente, non modificate niente, a meno di espressa autorizzazione del sottoscritto.

Sandbox n° 1 · Sandbox n°2 · Sandbox n°3 · Sandbox n°4 · Sandbox n°5 · Sandbox n°6

---

Sindrome dell'occhio fantasma en:Phantom eye syndrome

Sindrome dell'occhio fantasma

Template:Disclaimer medico Template:Infobox Malattia

La sindrome dell'occhio fantasma è un dolore fantasma all'occhio, con possibili allucinazioni, che si può manifestare dopo la rimozione dell'occhio.

Sintomatologia

Molti pazienti lamentano uno o più fenomeni fantasma dopo la rimozione dell'occhio:

• Dolore fantasma all'occhio rimosso (prevalenza del 26%)^[1];
• sensazioni fantasma di natura non dolorosa^[1];
• allucinazioni visive: circa il 30% dei pazienti accusa allucinazioni dall'occhio rimosso^[1]. La maggior parte di queste allucinazioni consiste in percezioni visive di base (forme e colori). Al contrario, allucinazioni visive causate da perdite della vista sono meno comuni (casistica del 10% circa), e consistono spesso in immagini dettagliate.

Pathogenesis

Phantom pain and non-painful phantom sensations

Phantom pain and non-painful phantom sensations result from changes in the central nervous system due to denervation of a body part.^[2][3] Phantom eye pain is considerably less common than phantom limb pain. The prevalence of phantom pain after limb amputation ranged from 50% to 78%. The prevalence of phantom eye pain, in contrast, is about 30%.

Post-amputation changes in the cortical representation of body parts adjacent to the amputated limb are believed to contribute to the development of phantom pain and nonpainful phantom sensations. One reason for the smaller number of patients with phantom eye pain compared with those with phantom limb pain may be the smaller cortical somatosensory representation of the eye compared with the limbs.

In limb amputees, some^[3] but not all studies have found a correlation between preoperative pain in the affected limb and postoperative phantom pain. There is a significant association between painful and nonpainful phantom experiences and preoperative pain in the symptomatic eye and headache.^[4] Based on the present data it is difficult to determine if headaches or preoperative eye pain play a causal role in the development of phantom phenomena, or if headache, preoperative eye pain, and postoperative phantom eye experiences are only epiphenomena of an underlying factor. However, a study in humans demonstrated that experimental pain leads to a rapid reorganization of the somatosensory cortex.^[5] This study suggests that preoperative and postoperative pain may be an important cofactor for somatosensory reorganization and the development of phantom experiences.

Visual hallucinations

Enucleation of an eye and, similarly, retinal damage, lead to a cascade of events in the cortical areas receiving visual input. Cortical GABAergic (GABA: Gamma-aminobutyric acid) inhibition decreases and cortical glutamatergic excitation increases, followed by increased visual excitibility or even spontaneous activity in the visual cortex.^[6] It is believed that spontaneous activity in the denervated visual cortex is the neural correlate of visual hallucinations.

See also

• Visual system
• Charles Bonnet syndrome

References

1. (EN) P. Sörös, O. Vo, I.-W. Husstedt, S. Evers, H. Gerding, hantom eye syndrome: Its prevalence, phenomenology, and putative mechanisms, in Neurology, vol. 60, n. 9, Maggio 2003, pp. 1542-3, 12743251.
2. ^ Vilayanur S. Ramachandran, W Hirstein, The perception of phantom limbs. The D. O. Hebb lecture, in Brain, vol. 121, n. 9, September 1998, pp. 1603–30, DOI:10.1093/brain/121.9.1603. URL consultato il 23 settembre 2008.
3. L. Nikolajsen, T. S. Jensen, Phantom limb pain, in British Journal of Anaesthesia, vol. 87, n. 1, July 2001, pp. 107–16, DOI:10.1093/bja/87.1.107. URL consultato il 23 settembre 2008. Errore nelle note: Tag <ref> non valido; il nome "Nikolajsen" è stato definito più volte con contenuti diversi
4. ^ M. Nicolodi, R. Frezzotti, A. Diadori, A. Nuti and F. Sicuteri, Phantom eye: features and prevalence. The predisposing role of headache, in Cephalalgia, vol. 17, n. 4, June 1997, pp. 501–4, DOI:10.1046/j.1468-2982.1997.1704501.x. URL consultato il 23 settembre 2008.
5. ^ Peter Sörös, Stefan Knechta, Carsten Bantelb, Tanya Imaia, Rainer Wüstenb, Christo Pantevc, Bernd Lütkenhönerc, Hartmut Bürkleb and Henning Henningsen, Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography, in Neuroscience Letters, vol. 298, n. 3, February 2001, pp. 195–8, DOI:10.1016/S0304-3940(00)01752-3. URL consultato il 23 settembre 2008.
6. ^ Ulf T. Eysel, Georg Schweigart, Thomas Mittmann, Dirk Eyding, Ying Qu, Frans Vandesande, Guy Orban and Lutgarde Arckens, Reorganization in the visual cortex after retinal and cortical damage, in Restorative Neurology and Neuroscience, vol. 15, n. 2-3, 1999, pp. 153–64. URL consultato il 23 settembre 2008.

External links

• Jonathan Cole, Phantom limb pain, su wellcome.ac.uk, Wellcome Trust. URL consultato il 23 settembre 2008.
• http://psy.ucsd.edu/chip/ramabio.html Homepage of Vilayanur S. Ramachandran

[[Category:Visual system]] [[Category:Neurology]] [[Category:Neurological disorders]] [[Category:Ophthalmology]] [[Category:Syndromes]] [[hr:Sindrom fantomskog oka]]