The term big shot can refer to:
- A slang term for a Very Important Person, executive, business magnate or media mogul
- A song by Billy Joel, which appeared on his album 52nd Street
- A superhero character named Big Shot from the animated television series The Tick, is a parody of The Punisher
- An amusement ride on top of the Stratosphere Las Vegas tower
- A Louisiana-based brand of soda