NSE may be:
- National Society for Epilepsy, a UK-based epilepsy charity.
- National Spanish Examination (United States)
- National Student Exchange (United States, Canada)
- Nagoya Stock Exchange (Japan)
- National Stock Exchange of India
- Network SouthEast, a former sector of British Rail.
- Network Search Engine also known as Network Search Element -- components of computer network infrastructure that accelerate one of the most common function: searching for patterns/ addresses in data packets.
- Neuron-specific enolase
- North-South Expressway (Malaysia)
- Nigerian Stock Exchange
- Nairobi Stock Exchange