Introduction[edit]
Cellular memory modules are a form of epigenetic inheritance that allow cells to maintain their original identity after a series of cell divisions and developmental processes. Cellular memory modules implement these preserved characteristics into transferred environments through transcriptional memory [1]. Cellular memory modules are primarily found in Drosophila.
History
Cellular memory modules were discovered by François Jacob and Jaques Monod in 1961 at the Pasteur Institute in Paris. The discovery led to Jacob and Monod, along with André Lwoff, receiving The Nobel Prize in Physiology or Medicine in 1965 for their discoveries regarding genetic control of enzyme and virus synthesis. These experimental results mapped the complex processes in which self-regulating processes express or suppress genes. Monod and Jacob proved how genetic information conversion during the construction of proteins was done through a messenger which evinced RNA [2]. Lwoff aided in the experiment that won the Nobel Prize but did not work on the series of experiments that led to the discovery of cellular memory modules, which is why he remains uncredited in its discovery.
References
- ^ Paro, Renato; Grossniklaus, Ueli; Santoro, Raffaella; Wutz, Anton (2021), Paro, Renato; Grossniklaus, Ueli; Santoro, Raffaella; Wutz, Anton (eds.), "Cellular Memory", Introduction to Epigenetics, Cham: Springer International Publishing, pp. 49–66, doi:10.1007/978-3-030-68670-3_3, ISBN 978-3-030-68670-3, retrieved 2023-04-20
- ^ "The Nobel Prize in Physiology or Medicine 1965". NobelPrize.org. Retrieved 2023-04-18.
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