A nested case-control study is a type of study design where new case controls are applied into cohorts which were defined before the study begins.
Compared with case-control study, nested case-control study can reduce 'recall bias' and temporal ambiguity, and compared with cohort study, it can reduce cost and save time.
The drawback of nested case-control study is non-diseased persons from whom the controls are selected may not be fully representative of the original cohort due to death or failure to follow-up cases.
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