The Human Protein Reference Database is a protein database accessible through internet.[1]
This resource depicts information on human protein functions including protein-protein interactions, post-translational modifications, enzyme-substrate relationships and disease associations. Protein annotation information that is catalogued was derived through manual curation using published literature by expert biologists and through bioinformatics analyses of the protein sequence. The protein-protein interaction and subcellular localization data from HPRD have been used to develop a human protein interaction network.[2]
HPRD also integrates data from Human Proteinpedia, a community portal for integrating human protein data. The data from HPRD can be freely obtained and commercial entities may not use this site without prior licensing authorization. Human Proteinpedia[3] content is freely available for anyone to download and use.
HPRD data is available for download in tab delimited and XML file formats.
HPRD currently has 33,710 unique protein-protein interactions with experimental evidence for most of the interactions derived from in vivo, in vitro and yeast-two hybrid experiments.[4]
PhosphoMotif Finder
PhosphoMotif Finder[5] contains known kinase/phosphatase substrate as well as binding motifs that are curated from the published literature. It reports the PRESENCE of any literature-derived motif in the query sequence. PhosphoMotif Finder does NOT PREDICT any motifs in the query protein sequence using any algorithm or other computational strategies.
References
- ^ Peri et al. Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res. 2003 Oct;13:2363-71.
- ^ Gandhi et al. Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat. Genetics 2006 Mar;3:285-293.
- ^ Mathivanan et al. Human Proteinpedia enables sharing of human protein data. Nat Biotechnology. 2008 Feb;26:164-7
- ^ Mishra et al. Human protein reference database--2006 update. Nucleic Acids Res. 2006 Jan;34(Database issue):D411-4
- ^ Amanchy et al. A compendium of curated phosphorylation-based substrate and binding motifs. Nat Biotechnology. 25, 285-286
External links
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