Macarena may mean:
- Macarena. an aspect of the Virgin Mary recognized in Andalusia, Spain. It's the title given to Nuestra Señora de la Esperanza (Our Lady of Hope), in Seville.
- Macarena. the name of a neighbourhood in Seville and a common first name for Andalusian women.
- Macarena, a song by Los del Río.