The histone code hypothesis is more about the access of transcription factors and activation/repression of genes via open/closed conformation of chromatin. It doesn't really have to do with how DNA binds to histones. The main definition in this article is unclear. —Preceding unsigned comment added by 130.39.115.49 (talk) 21:06, 3 November 2008 (UTC) Template:WikiProject GeneticsTemplate:Wikiproject MCB