New York State Route 22 is the third longest of the New York State highways, only to be shorter than NY-5 and NY-17(which, recently, is being converted to I-86. Stretcing 341 miles (548 km) from The Bronx to the Canadian border in Mooers, New York, NY-22 was designed as a route from the Bronx to Canada. However, in recent years, the Taconic State Parkway and I-87 (New York State Thruway and Northway) have made NY-22 and obsolete choice for express travel, as it is a surface street which encounters stoplights. NY-22 follows I-684 within Putman County into Dutchess County where I-684 terminates at NY 22, US 6, and US 202. However, NY 22 still has local and regional importance.

Route 22 serves nine counties in New York: Bronx, Westchester, Putnam, Dutchess, Columbia, Rensselaer, Washington, Essex, and Clinton counties.
Concurrencies by County
None(See Historic notes)
Historic notes
- In the 1920s, Route 22 was known as New England Interstate Route 22, the westernmost north-south route of the New England Interstate Route system.
- NY 22 once went further south. It ran along 233rd Street, Jerome Avenue, Grand Concourse and 149th Street in the Bronx, and 145th Street, Lenox Avenue, 110th Street, and Park Avenue into Lower Manhattan. It was also concurrent with a former extension of NY 100 south of Jerome Avenue.