Mitochondrial translational release factor 1

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.^[5][6]

MTRF1
Identifiers
Aliases	MTRF1, MRF1, MTTRF1, RF1, mitochondrial translational release factor 1, mitochondrial translation release factor 1
External IDs	OMIM: 604601; MGI: 2384815; HomoloGene: 20903; GeneCards: MTRF1; OMA:MTRF1 - orthologs
Gene ___location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 41,216,369 bp[1] End 41,263,577 bp[1]
Gene ___location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 79,635,212 bp[2] End 79,661,027 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas rectum right adrenal gland right adrenal cortex gallbladder left adrenal gland granulocyte testicle left adrenal cortex body of stomach Top expressed in left ventricle interventricular septum quadriceps femoris muscle primary oocyte muscle tissue proximal tubule muscle of thigh skeletal muscle tissue right kidney ovary More reference expression data BioGPS n/a
Gene ontology Molecular function translation release factor activity translation release factor activity, codon specific ribosome binding Cellular component mitochondrion cytoplasm Biological process translational termination regulation of translational termination protein biosynthesis mitochondrial translational termination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9617 211253 Ensembl ENSG00000120662 ENSMUSG00000022022 UniProt O75570 Q8N6Z2 Q8K126 RefSeq (mRNA) NM_004294 NM_001354073 NM_001354074 NM_001354076 NM_145960 RefSeq (protein) NP_004285 NP_001341002 NP_001341003 NP_001341005 NP_666072 Location (UCSC) Chr 13: 41.22 – 41.26 Mb Chr 14: 79.64 – 79.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.

References

1. GRCh38: Ensembl release 89: ENSG00000120662 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022022 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
6. Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675.

Further reading

• Nozaki Y, Matsunaga N, Ishizawa T, et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes Cells. 13 (5): 429–38. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Soleimanpour-Lichaei HR, Kühl I, Gaisne M, et al. (2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG". Molecular Cell. 27 (5): 745–57. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939.
• Young DJ, Edgar CD, Murphy J, et al. (2010). "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria". RNA. 16 (6): 1146–55. doi:10.1261/rna.1970310. PMC 2874167. PMID 20421313.
• Huynen, MA, Martijn; Duarte I; Chrzanowska-Lightowlers ZM; Nabuurs SB. (8 May 2012). "Structure based hypothesis of a mitochondrial ribosome rescue mechanism". Biology Direct. 7 (1): 14. doi:10.1186/1745-6150-7-14. PMC 3418547. PMID 22569235.