Mucin 5B

Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene^[5][6][7][8] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions.^[9]

MUC5B
Identifiers
Aliases	MUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming
External IDs	OMIM: 600770; MGI: 1921430; HomoloGene: 136756; GeneCards: MUC5B; OMA:MUC5B - orthologs
Gene ___location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 1,223,066 bp[1] End 1,262,172 bp[1]
Gene ___location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 87.29 cM Start 141,392,807 bp[2] End 141,426,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trachea gallbladder mucosa of transverse colon olfactory zone of nasal mucosa bronchus epithelium of bronchus bronchial epithelial cell tendon of biceps brachii minor salivary glands mucosa of sigmoid colon Top expressed in trachea olfactory epithelium right lung cervix right lung lobe conjunctival fornix cochlea carotid body left lung zygote More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Golgi lumen extracellular region extracellular exosome intracellular membrane-bounded organelle plasma membrane extracellular space Biological process O-glycan processing stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 727897 74180 Ensembl ENSG00000117983 ENSMUSG00000066108 UniProt Q9HC84 n/a RefSeq (mRNA) NM_002458 NM_028801 RefSeq (protein) NP_002449 n/a Location (UCSC) Chr 11: 1.22 – 1.26 Mb Chr 7: 141.39 – 141.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synthesis

All mucins are synthesized in secretory cells known as goblet cells or mucous cells, depending on the tissue ___location. Their creation, while still not completely understood, begins in the endoplasmic reticulum. From there, the Golgi apparatus builds the O-linked glycans found in mucins. Finally, they are packaged into secretory granules.^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000117983 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066108 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Desseyn JL, Buisine MP, Porchet N, Aubert JP, Laine A (November 1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon". The Journal of Biological Chemistry. 273 (46): 30157–64. doi:10.1074/jbc.273.46.30157. PMID 9804771.
6. Desseyn JL, Guyonnet-Dupérat V, Porchet N, Aubert JP, Laine A (November 1997). "Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family". The Journal of Biological Chemistry. 272 (4): 3168–78. doi:10.1074/jbc.272.6.3168. PMID 9013550.
7. Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A (1997). "Genomic organization of the 3' region of the human mucin gene MUC5B". The Journal of Biological Chemistry. 272 (27): 16873–83. doi:10.1074/jbc.272.27.16873. PMID 9201995.
8. "Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming". ncbi.nlm.nih.gov.
9. "MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens (human)] - Gene - NCBI". ncbi.nlm.nih.gov. Retrieved 2021-06-10.
10. McGuckin MA, Thornton DJ, Whitsett JA (January 2015). "Mucins and mucus.". Mucosal Immunology. Academic Press. pp. 231–250. doi:10.1016/B978-0-12-415847-4.00014-8. ISBN 9780124158474.