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Science
- Brian Duffy, astronaut
- Howard A. Kelly, John Hopkins founding physicians
- John Philip Holland, inventor of the submarine, Fenian
- Arthur Edwin Kennelly, electrical engineer
- Charles McBurney, medical pioneer
- Charles Townes, physicist, Nobel Prize in Physics laureate
Music
- Christina Aguilera, singer
- Chris Byrne, Black 47 member
- Dennis Casey, Flogging Molly member
- Ken Casey, Dropkick Murphys member
- Mariah Carey, singer
- Hoagy Carmichael, composer
- Liam Clancy, Clancy Brothers
- Patrick Clancy, Clancy Brothers
- Tom Clancy, Clancy Brothers
- Rosemary Clooney, singer
- Eddie Cochran, singer
- George M. Cohan, composer
- Judy Collins, guitarist
- Jimmy Dorsey, composer
- Tommy Dorsey, composer
- Everlast, singer
- Eileen Farrell, singer
- Stephen Foster, songwriter
- Victor Herbert, conductor
- Mike Kelly, Dropkick Murphys member
- Larry Kirwan, Black 47 member
- Liam Lynch, singer
- Tommy Makem, Clancy Brothers member
- Mike McColgan, Dropkick Murphys member
- John F. McCormack, tenor
- John McLaughlin, guitarist
- Thomas Moore, composer
- Jim Morrison, The Doors member
- Gerry Mulligan, jazz musician
- Daniel O'Connor, singer
- Patti Smith, singer, poet
Literature
- Raymond Chandler, novelist
- Kate Chopin, short stories writer
- Tom Clancy, novelist
- Mary Higgins Clark, writer
- Robert Creeley, poet
- Elizabeth Cullinan, author
- J.P. Donleavy, author
- Finley Peter Dunne, writer
- James T. Farrell, novelist
- F. Scott Fitzgerald, novelist
- Thomas Flanagan, author
- Robert Frost, poet
- Louise I. Guiney, poet
- William Kennedy, novelist
- James Laughlin, poet
- Cormac McCarthy, novelist
- Mary McCarthy, novelist
- Frank McCourt, writer
- Phyllis McGinley, poet
- James McGowan, writer
- Tim O'Brien, novelist
- Edwin O'Connor, author
- Flannery O'Connor, writer
- Frank O'Hara, poet
- John O'Hara, novelist
- Eugene O'Neill, playwright
- John Boyle O'Reilly, poet
- James W. Riley, poet
Arts
Entertainment
- Don Adams, actor
- Ben Affleck, actor
- Casey Affleck, actor
- Alec Baldwin, actor
- Stephen Baldwin, actor
- Lionel Barrymore, actor
- Warren Beatty, actor
- Ed Begley, actor
- Dion Boucicault, actor, playwright
- Lara Flynn Boyle, actress
- Peter Boyle, actor
- Ed Burns, actor, director
- Steve Buscemi, actor
- Ellen Burstyn, actress
- Alice Brady, actress
- Marlon Brando, actor
- Walter Brennan, actor
- Matthew Broderick, actor
- James Cagney, actor
- George Carlin, comedian
- Art Carney, actor
- Dana Carvey, actor
- Lenny Clarke, comedian
- George Clooney, actor
- William Cody, showman
- Jennifer Connelly, actress
- Kevin Connolly, actor
- Kevin Corrigan, actor
- Kevin Costner, actor
- Nikki Cox, actress
- Bing Crosby, singer, actor
- Joan Cusack, actress
- John Cusack, actor
- Tim Daly, actor
- Rosario Dawson, actress
- Carson Daly, talk show host
- Robert De Niro, actor
- Brian Dennehy, actor
- Walt Disney, producer, screenwriter, animator
- Shannen Doherty, actress
- Robert Downey, Jr., actor
- Brian Doyle-Murray, actor
- James Dunn, actor
- Nora Dunn, actress
- Emilio Estevez, actor
- Jimmy Fallon, actor
- Chris Farley, actor
- Mia Farrow, actress
- Will Ferrell, actor
- Barry Fitzgerald, actor
- Michael Flatley, dancer
- Errol Flynn, actor
- Harrison Ford, actor
- John Ford, director
- Jodie Foster, actress
- Judy Garland, actress
- Janeane Garofalo, actress
- Greer Garson, actress
- Richard Gere, actor
- Peri Gilpin, actress
- Jackie Gleason, actor
- Lauren Graham, actress
- Kathy Griffin, comedian
- Helen Hayes, actress
- Susan Hayward, actress
- Patricia Heaton, actress
- Bonnie Hunt, actress
- Anjelica Huston, actress
- John Huston, director
- Walter Huston, actor
- Buster Keaton, actor
- David E. Kelley, producer
- Gene Kelly, dancer, actor
- Grace Kelly, actress
- Robert Kelly, comedian
- George Kennedy, actor
- Kevin Kline, actor
- Denis Leary, actor
- Jack Lemmon, actor
- Donal Logue, actor
- Lindsay Lohan, actress
- Richard Lynch, actor
- Seth MacFarlane, cartoonist
- Kathleen Madigan, comedian
- Tobey Maguire, actor
- Bill Maher, comedian
- John Mahoney, actor
- Dorothy Malone, actress
- Christopher Masterson, actor
- Danny Masterson, actor
- Leo McCarey, director
- Jenny McCarthy, actress
- Maureen McCormick, actress
- Dylan McDermott, actor
- Ted McGinley, actor
- Victor McLaglen, actor
- Steve McQueen, actor
- Thomas Mitchell, actor
- Julianne Moore, actress
- Michael Moore, director
- Mary Tyler Moore, actress
- Erin Moran, actress
- Michael Moriarty, actor
- Megan Mullally, actress
- Bill Murray, actor
- Patricia Neal, actress
- Kevin Nealon, comedian
- Jack Nicholson, actor
- Annie Oakley, sharpshooter
- Conan O'Brien, comedian
- Edmund O'Brien, actor
- Pat O'Brien, actor
- Jerry O'Connell, actor
- Carroll O'Connor, actor
- Donald O'Connor, actor
- Raymond O'Connor, actor
- Renee O'Connor, actress
- Chris O'Donnell, actor
- Rosie O'Donnell, actress, comedian
- Maureen O'Hara, actress
- Mike O'Malley, actor
- Ryan O'Neal, actor
- Tatum O'Neal, actress
- Ed O'Neill, actor
- Kitty O'Neill, stuntwoman
- Bill O'Reilly, commentator
- Maureen O'Sullivan, actress
- Annette O'Toole, actress
- Gregory Peck, actor
- Tyrone Power, actor
- Regis Philbin, television personality
- Anthony Quinn, actor
- Colin Quinn, comedian
- Robert Redford, actor, director
- John C. Reilly, actor
- Burt Reynolds, actor
- Jason Robards, actor
- Mickey Rourke, actor
- Susan Sarandon, actress
- Molly Shannon, actress
- Charlie Sheen, actor
- Martin Sheen, actor
- Brooke Shields, actress
- Ben Stiller, actor
- Ed Sullivan, television personality
- Julia Sweeney, actress
- Maura Tierney, actress
- Spencer Tracy, actor
- Robin Tunney, actress
- John Wayne, actor
Sports
- Rick Barry, basketball player
- James J. Braddock, boxer
- Bill Bradley, basketball player
- Tom Brady, football player
- Joe Brennan, basketball player
- Roger P. Bresnahan, baseball player
- Patrick Burke, first Irish-born basketball player to play in the NBA
- Max Carey, baseball player
- Matt Carroll, basketball player
- Mickey Cochrane. baseball player
- Eddie Collins, baseball player
- Kerry Collins, football player
- Charles Comiskey, baseball player, White Sox owner
- Maureen C. Connolly, tennis player
- George Connor, football player
- Jimmy Connors, tennis player
- James J. Corbett, boxer
- Joe Cronin, baseball player
- Chuck Daly, basketball coach
- Jack Dempsey, boxer
- Matt Doherty, basketball coach
- Art Donovan, football player
- Paddy Driscoll, football player
- John Duddy, boxer
- Hugh Duffy, baseball player
- Ryan Fitzpatrick, football player
- Ray Flaherty, football coach
- Mike Flanagan, football player
- Peggy Fleming, figure skater
- Mike Flynn, football player
- Jeff Garcia, football player
- Pat Garrity, basketball player
- Frank Gifford, football player
- Dorothy Hamill, figure skater
- Joey Harrington, football player
- Ed Healey, football player
- Ben Hogan, golfer
- Derek Jeter, baseball player
- Bobby Jones, golfer
- Jim Kelly, football player
- Johnny Kerr, basketball player
- Nancy Kerrigan, figure skater
- Frank Leahy, football coach
- Ed Macauley, basketball player
- Matt Maloney, basketball player
- Kevin McBride, boxer
- Brandon McCarthy, baseball player
- Mike McCormack, football player
- John McDermott, golfer
- Robert McDermott, basketball player
- John McEnroe, tennis player
- Dylan McFarland, football player
- Al McGuire, basketball player
- Dick McGuire, basketball player
- Mark McGwire, baseball player
- Kevin McHale, basketball player
- Sean McHugh, football player
- Jim McMahon, football player
- Mike McMahon, football player
- Pete McMahon, football player
- Peter McNeeley, boxer
- Ian Moran, hockey player
- Tommy Morrison, boxer
- Joe Mullen, hockey player
- Chris Mullin, basketball player
- Stretch Murphy, basketball player
- Bill Murphy, baseball player
- Bob Murphy, boxer
- Troy Murphy, basketball player
- Neil O'Donnell, football player
- Matt O'Dwyer, football player
- Shaun O'Hara, football palyer
- Troy O'Leary, baseball player
- Keith O'Neil, football player
- Paul O'Neill, baseball player
- Dennis O'Sullivan, football player
- J.T. O'Sullivan, football player
- Danica Patrick, auto racer
- Jonathon Quinn, football player
- Pat Riley, basketball coach
- Art Rooney, one of the NFL creators
- Nolan Ryan, baseball player
- Tom Sharkey, boxer
- Patty Sheehan, golfer
- Sam Snead, golfer
- John L. Sullivan, boxer
- Pat Sullivan, football player
- Don Sutton, baseball player
- Gene Tunney, boxer
- Bill Walsh, football coach
Military
- John Adams, Confederate States Army brigadier-general
- John Barry, Father of the United States Navy
- Patrick Cleburne, Confederate States Army major-general
- Michael Corcoran, United States Army general
- John Devoy, Fenian
- William Donovan, head of the Office of Strategic Services during WW II
- Jubel Early, Confederate States Army brigadier-general
- Joseph Finegan, Confederate States Army general
- James Hickey, Operation Red Dawn leader
- Henry Knox, Continental Army general
- Thomas "Stonewall" Jackson, Confederate States Army major-general
- Andrew Lewis, Continental Army general
- Jessica Lynch, soldier in Second Gulf War
- Alfred Thayer Mahan, United States Navy officer, author
- John McCausland, Confederate States Army brigadier-general
- John E. McLaughlin, former acting Director of the CIA
- John McCone, CIA Director 1961-65
- Thomas F. Meagher, United States Army general, Fenian
- Richard Montgomery, Continental Army general
- Patrick Moore, Confederate States Army brigadier-general
- Audie Murphy, most decorated combat soldier of World War II
- Timothy Murphy, marksman, Continental Army
- Jeremiah O'Brien, captain in Continental Navy
- Edward "Butch" O'Hare, America's first World War II flying ace
- John O'Mahony, Fenian
- John O'Neill, United States Army general, Fenian
- Oliver Perry, United States Navy commodore, forced Japan to open to international trade
- John Stark, Continental Army general
- Walter Stewart, Continental Army general
- James Stuart, Confederate Army brigadier-general
- John Sullivan, Continental Army general
- Anthony Wayne, Continental Army general
Politics
- Chester A. Arthur, US president
- James G. Barry, St. Louis mayor
- William B. Barry, US Congressman
- Edward P. Boland, US Congressman
- James Buchanan, US President
- Chris Buckley, San Francisco Democratic party leader
- Aedanus Burke, US Congressman
- Thomas Burke, North Carolina governor
- Thomas A. Burke, Cleveland mayor, US Senator
- Bob Brady, US Congressman
- David C. Broderick, US Senator
- Edmund G. Brown, California governor
- Jerry Brown, California governor, Oakland mayor
- John T. Browne, Houston mayor
- Brendan Byrne, New Jersey governor
- Emmet F. Byrne, US Congressman
- Jane Byrne, Chicago mayor
- Thomas R. Byrne, St. Paul mayor
- James F. Byrnes, US Senator
- John C. Calhoun, US Vice President
- Bryan Callaghan, San Antonio mayor
- Hugh Carey, New York governor
- Charles Carroll, signatory to the Declaration of Independence
- Robert P. Casey, Pennsylvania governor
- Eugene Casserly, US Senator
- Jerome Cavanagh, Detroit mayor
- John Michael Clancy, US Congressman
- Grover Cleveland, US president
- Bill Clinton, US President
- De Witt Clinton, New York City mayor
- W. Bourke Cockran, US Congressman
- John Conness, US Senator
- James F. Conway, St. Louis mayor
- Patrick Collins, Boston mayor
- James Cooney, US Congressman
- John Coughlin, First Ward Alderman in Chicago 1893-1938
- William Cullen, US Congressman
- James Michael Curley, Boston mayor
- Thomas Cusack, US Congressman
- Richard Croker, New York City mayor
- Joseph Crowley, US Congressman
- Richard J. Daley, Chicago mayor
- Richard M. Daley, Chicago mayor
- William M. Daley, U.S. Secretary of Commerce
- John C. Daubney, St. Paul mayor
- John Darraugh, Pittsburgh mayor
- William Dawson, St. Paul mayor
- Edward K. Delaney, St. Paul mayor
- John Delaney, Jacksonville mayor
- John Dempsey, Connecticut governor
- Éamon de Valera, President of Ireland (American-born)
- John Devoy, Fenian
- Joseph E. Dillon, St. Paul mayor
- Richard A. Donnelly, Trenton mayor
- Michael Donohoe, US Congressman
- Frank Doran, St. Paul mayor
- James Doyle, Wisconsin governor
- Mike Doyle, US Congressman
- Thomas A. Doyle, US Congressman
- John G. Downey, California governor
- F. Ryan Duffy, US Senator
- Edward Fitzsimmons Dunne, Chicago mayor
- Mark M. Fagan, Jersey City mayor
- Mike Fahey, Omaha mayor
- Thomas Fallon, San Jose mayor
- William H. Fallon, St. Paul mayor
- James A. Farley, Chairman of the Democratic National Committee, US Postmaster General
- Patrick Farrelly, US Congressman
- Michael A. Feighan, US Congressman
- John Frederick Finerty, US Congressman
- John F. Fitzgerald, Boston mayor
- Thomas Fitzsimons, US Congressman
- John Fitzpatrick, New Orleans mayor
- Mike Fitzpatrick, US Congressman
- Lawrence James Flaherty, US Congressman
- Peter F. Flaherty, Pittsburgh mayor
- Michael P. Flanagan, US Congressman
- Ed Flynn, Chairman of the Democartic National Committee
- Raymond Flynn, Boston mayor
- William S. Flynn, Rhode Island governor
- Nicholas Ford, US Congressman
- Thomas Gallagher, Pittsburgh mayor
- Martin Galvin, founder of NORAID
- J. Joseph Garrahy, Rhode Island governor
- Martin H. Glynn, New York governor
- Charles P. Gillen, Newark mayor
- Thomas F. Gilroy, New York City mayor
- Patrick Gleason, Long Island City politcal machine boss
- William R. Grace, New York City mayor
- J. Harold Grady, Baltimore mayor
- Ulysses S. Grant, US President
- James Griffin, Buffalo mayor
- Michael Griffin, US Congressman
- Frank Hague, Jersey City mayor
- James M. Hanley, US Congressman
- Robert P. Hanrahan, US Congressman
- Jerramiah T. Healy, Jersey City mayor
- James J. Heffernan, US Congressman
- Brian Higgins, US Congressman
- John Hogan, US Congressman
- William Hooper, signatory to the Declaration of Independence
- John Patrick Hopkins, Chicago mayor
- John C. Houlihan, Oakland mayor
- William Hughes, US Senator
- Denis M. Hurley, US Congressman
- Andrew Jackson, US president
- Nicholas T. Kane, US Congressman
- Frank Keating, Oklahoma governor
- Augustine B. Kelley, US Congressman
- Patrick H. Kelley, US Congressman
- Edward A. Kelly, US Congressman
- Edward Joseph Kelly, Chicago mayor
- John Kelly, Tammany Hall boss
- Joseph J. Kelly, Buffalo mayor
- Randy Kelly, St. Paul mayor
- Michael Kenna, First Ward Alderman in Chicago 1897-1923
- Edward Kennedy, US Senator
- John F. Kennedy, US President
- Joseph Kennedy, rumrunner, U.S. ambassador
- Mark Kennedy, US Congressman
- Patrick J. Kennedy, US Congressman
- Robert F. Kennedy, US Senator
- Martin H. Kennelly, Chicago mayor
- Richard Kyrle, South Carolina governor
- Philip Livingston, signatory to the Declaration of Independence
- William Livingston, first Governor of New Jersey
- Patrick Leahy, US Senator
- James Logan, statesman
- Huey Long, Louisiana governor
- Robert Lowry, US Congressman
- Thomas Lynch, signatory to the Declaration of Independence
- Lisa Madigan, Illinois Attorney General
- Michael Madigan, Illinois Speaker of the House, Illinois Democratic Party Chairman
- George Maguire, St. Louis mayor
- William Mahoney, St. Paul mayor
- Mike Mansfield, US Senator, Ambassador
- William McAleer, US Congressman
- John McCain, US Senator
- Gerald McCann, Jersey City mayor
- Patrick McCarran, US Senator
- Carolyn McCarthy, US Congressman
- Eugene McCarthy, US Senator
- Joseph McCarthy, US Senator
- P.H. McCarthy, San Francisco mayor
- William C. McCarthy, Pittsburgh mayor
- Frank McCoppin, San Francisco mayor
- John W. McCormack, Speaker of the House
- Jim McDermott, US Congressman
- John J. McDonough, St. Paul mayor
- Lawrence E. McGann, US Congressman
- George McGovern, US Senator
- Jim McGovern, US Congressman
- John J. McGrath, US Congressman
- J. Howard McGrath, US Senator, Rhode Island governor
- James McGreevey, New Jersey governor
- Thomas McKean, signatory to the Declaration of Independence
- Bernard J. McKenna, Pittsburgh mayor
- Joseph McKenna, US Attorney General
- William McKinley, US President
- Hugh McLaughlin, Brooklyn Democratic party boss
- Joseph McLaughlin, US Congressman
- Frank J. McNulty, US Congressman
- Marty Meehan, US Congressman
- John Purroy Mitchel, New York City mayor
- Thomas Monahan, San Jose mayor
- Robert M. Moore, Cincinnati mayor
- Jim Moran, US Congressman
- John Morrissey, US Congressman
- Daniel Patrick Moynihan, US Senator
- P.H. Moynihan, US Congressman
- William J. Moxley, US Congressman
- Bryan Mullanphy, St. Louis mayor
- James C. Murray, US Congressman
- Bernard D. Murphy, San Jose mayor
- Charles F. Murphy, Tammany Hall boss
- Dick Murphy, San Diego mayor
- Frank Murphy, Detroit mayor, Michigan governor
- George Murphy, US Senator
- Isaac Murphy, Arkansas governor
- Morgan F. Murphy, US Congressman
- Timothy Murphy, US Congressman
- Tom Murphy, Pittsburgh mayor
- William T. Murphy, US Congressman
- Richard Neal, US Congressman
- Thomas Nelson, signatory to the Declaration of Independence
- Michael N. Nolan, Albany mayor
- Edward A. Noonan, St. Louis mayor
- Mary T. Norton, US Congressman
- Frank O'Bannon, Indiana governor
- Charles M. O'Brien, San Jose mayor
- Christopher D. O'Brien, St. Paul mayor
- George M. O'Brien, US Congressman
- Hugh O'Brien, Boston's first Irish mayor
- James O'Brien, US Congressman
- John P. O'Brien, New York City mayor
- Thomas J. O'Brien, US Congressman
- Dan O'Connell, Albany mayor
- Bob O'Connor, Democratic canidate for Mayor of Pittsburgh
- Maureen O'Connor, San Diego mayor
- Thomas O'Connor, Tammany Hall leader
- Herbert R. O'Conor, Maryland governor
- William O'Dwyer, New York City mayor
- Barratt O'Hara, US Congressman
- Arthur J. O'Keefe, New Orleans mayor
- Martin O'Malley, Baltimore mayor
- John H. O'Neall, US Congressman
- Charles H. O'Neill, Jersey City mayor
- Thomas O'Neill, Speaker of the House
- William A. O'Neill, Connecticut governor
- Daniel O'Reilly, US Congressman
- George F. O'Shaunessy, US Congressman
- George Pataki, New York governor
- Thomas M. Patterson, US Congressman
- Colin Powell, 65th Secretary of State
- Tom Pendergast, Kansas City Democratic machine boss
- James D. Phelan, San Francisco mayor, US Senator
- George Washington Plunkitt, Tammany Hall member
- James Polk, US President
- Jack Quinn, US Congressman
- John Quinn, US Congressman
- Liam Quinn, Provisional IRA volunteer
- George Read, signatory to the declaration of Independence
- Ronald Reagan, US President
- Thomas Reilly, Massachusetts Attorney General
- Richard Riordan, Los Angeles mayor
- William R. Roberts, US Congressman
- John J. Rooney, US Congressman
- Edward Rutledge, signatory to theDeclaration of Independence
- George H. Ryan, Illinois governor
- Jim Ryan, Illinois Attorney General
- Paul Ryan, US Congressman
- Tim Ryan, US Congressman
- William Ryan, US Congressman
- Thomas Shannon, US Congressman
- Wilson Shannon, Ohio governor
- William F. Sheehan, Buffalo democratic machine boss
- James Shields, US Senator
- Al Smith, New York governor, Democratic Party presidential candidate
- James Smith, signatory to the Declaration of Independence
- P.J. Somers, Milwaukee mayor
- James Sullivan, Massachusetts governor
- Patrick Joseph Sullivan, US Senator
- Michael J. Stack, US Congressman
- George Taylor, signatory to the Declaration of Independence
- Charles Thomson, secretary to the Continental Congress
- Matthew Thornton, signatory to the Declaration of Independence
- John F. Tierney, US Congressman
- John V. Tunney, US Senator
- David I. Walsh, Massachusetts' first Catholic governor
- Michael Walsh, US Congressman
- Patrick Walsh, US Senator
- Thomas Walsh, US Attorney General
- Thomas William Ward, Austin mayor
- Thomas A. E. Weadock, US Congressman
- James Wilson, signatory to the Declaration of Independence
- Woodrow Wilson, US President
- William Whipple, signatory to the Declaration of Independence
- Kevin White, Boston mayor
Religion
- Philip Berrigan, Internationally renowned peace activist and Roman Catholic priest
- William Brady, Archbishop of St. Paul
- Raymond Leo Burke, Archbishop of St. Louis
- John Carroll, America's first Catholic bishop and founder of Georgetown University
- John Cardinal Cody, Archbishop of Chicago
- R. Luke Concanen, Bishop of New York
- John Connolly, Bishop of New York
- Michael Corrigan, Archbishop of New York
- Michael J. Curley, Archbishop of Baltimore
- James Duggan, Bishop of Chicago
- Philip Embury, founder of first Methodist church in U.S.
- Edward Cardinal Egan, Archbishop of New York
- John Cardinal Farley, Archbishop of New York
- Patrick Feehan, Archbishop of Chicago
- Harry Flynn, Archbishop of Saint Paul and Minneapolis
- James Augustine Healy, Bishop of Portland, Maine
- Patrick Healy, S.J., President of Georgetown College
- John Hughes, Archbishop of New York
- John Ireland, Archbishop of St. Paul
- Andrew Greeley, Roman Catholic priest, author and sociologist
- Roger Cardinal Mahony, Archbishop of Los Angeles
- Francis Makemie, founder of Presbyterianism in North America
- Theodore Cardinal McCarrick, Archbishop of Washington D.C.
- John Cardinal McCloskey, Archbishop of New York
- Michael J. McGivney, Knights of Columbus founder, priest
- John Murray, Archbishop of St. Paul
- John Cardinal O'Connor, Archbishop of New York
- Sean O'Malley, Archbishop of Boston
- Anthony O'Regan, Bishop of Chicago
- James Quigley, Archbishop of Chicago
- Fulton J. Sheen, Roman Catholic Archbishop
- Samuel Cardinal Stritch, Archbishop of Chicago
- John Timon, first bishop of Buffalo
- Thomas Walsh, Archbishop of Newark
Gangsters
- James J. Bulger, South Boston, FBI Ten Most Wanted
- Mad Dog Coll, New York City, Irish enforcer for mafia
- Jimmy Burke, New York City, depicted by Robert De Niro in Goodfellas
- John Burke, Chicago, Retired Mob leader, former fireman
- James Coonan, New York City, Westies leader
- Jack Diamond, New York City, bootlegger
- Bill Dwyer, New York City, prohibition gangster
- Mickey Featherstone, New York City, Westies member
- Richie Fitzpatrick, New York City, gunman, Monk Eastman and Five Points Gang member
- Stephen Flemmi, Boston, hitman for Whitey Bulger
- Jimmy Flynn, Boston, Winter Hill Gang member
- Vannie Higgins, New York City, bootlegger, known as Brooklyn's Last Irish Boss
- Henry Hill, New York City, basis for Goodfellas
- George Kelly, Chicago, hitman
- Owney Madden, New York
- Frank McErlane, Chicago, prohibition gang leader
- Bernard McLaughlin, Boston, Charlestown Mob leader
- Bugs Moran, Chicago, Al Capone rival
- Dion O'Banion, Chicago, prohibition gang leader
- Edward O'Donnell, Chicago, prohibition gang leader
- Jim O'Leary, Chicago, illegal gambling racketeer
- Willie Sutton, New York City, prolific bank robber
- Johnny Walsh, New York City, gang leader
Others
- Nellie Bly, journalist
- William Bonney, gunslinger
- Daniel Boone, explorer
- Brooke Burke, model
- Frances Marie Burke, Miss America
- Brooke Burns, model
- William J. Brennan, Jr., Supreme Court Justice
- Teri Byrne, model
- Neal Cassady, icon of the Beat Generation
- Eugene "Bull" Connor, public safety commissioner, Birmingham, Alabama
- Davy Crockett, patriot
- Patricia Donnelly, Miss America
- John Dunlap, printer, printed the first copies of the Declaration of Independence
- Carmen Electra, model
- Tiffany Fallon, Playmate of the Year
- Shandi Finnessey, Miss USA
- Henry Ford, founder of Ford Motor Company
- Patrick Ford, founder of The Irish World newspaper
- Anne Glover, hanged as a witch in Boston
- Dan Harrington, world poker champion
- William Randolph Hearst, publisher
- James Hoban, the Architect of the White House in Washington, DC
- Kathy Ireland, model
- Raymond W. Kelly, NYPD Commissioner
- Bat Masterson, U.S. Marshal, Dodge City
- Karen McDougal, Playmate of the Year
- Patti McGuire, Playmate of the Year
- Tom Monaghan, founder of Domino's Pizza
- Paul Morphy, chess player
- Soledad O'Brien, journalist
- John L. O'Sullivan, newspaper editor, coined the phrase "Manifest Destiny"
- Andy Rooney, journalist
- Diane Sawyer, news anchor
- Louis Sullivan, the father of American architecture
- John F. Timoney, Philadelphia Police Commissioner