CYTH3

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.^[5][6]

CYTH3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KAX
Identifiers
Aliases	CYTH3, ARNO3, GRP1, PSCD3, cytohesin 3, cytohesin-3
External IDs	OMIM: 605081; MGI: 1335107; HomoloGene: 3116; GeneCards: CYTH3; OMA:CYTH3 - orthologs
Gene ___location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 6,161,776 bp[1] End 6,272,644 bp[1]
Gene ___location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 82.36 cM Start 143,608,202 bp[2] End 143,696,005 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell visceral pleura parietal pleura middle temporal gyrus Brodmann area 23 spinal ganglia trigeminal ganglion saphenous vein tendon of biceps brachii tibia Top expressed in superior cervical ganglion right lung carotid body right lung lobe barrel cortex iris left lung ciliary body endothelial cell of lymphatic vessel fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatidylinositol-3,4,5-trisphosphate binding guanyl-nucleotide exchange factor activity lipid binding Cellular component cytoplasm ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane membrane Golgi membrane cytosol nucleoplasm adherens junction bicellular tight junction cell junction Biological process regulation of ARF protein signal transduction Golgi vesicle transport positive regulation of cell adhesion establishment of epithelial cell polarity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9265 19159 Ensembl ENSG00000008256 ENSMUSG00000018001 UniProt O43739 O08967 RefSeq (mRNA) NM_004227 NM_001163548 NM_011182 RefSeq (protein) NP_004218 NP_001354509 NP_001354510 NP_001354511 NP_001157020 NP_035312 Location (UCSC) Chr 7: 6.16 – 6.27 Mb Chr 5: 143.61 – 143.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 ___domain, and a C-terminal pleckstrin homology (PH) ___domain. The coiled-coil motif is involved in homodimerization, the Sec7 ___domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH ___domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000008256 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018001 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP (Apr 1997). "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains". Science. 275 (5308): 1927–30. doi:10.1126/science.275.5308.1927. PMID 9072969. S2CID 40523716.
6. "Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3".

Further reading

• Franco M, Boretto J, Robineau S, et al. (1998). "ARNO3, a Sec7-___domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9926–31. Bibcode:1998PNAS...95.9926F. doi:10.1073/pnas.95.17.9926. PMC 21438. PMID 9707577.
• Venkateswarlu K, Gunn-Moore F, Oatey PB, et al. (1998). "Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology ___domain". Biochem. J. 335 ( Pt 1) (Pt 1): 139–46. doi:10.1042/bj3350139. PMC 1219762. PMID 9742223.
• Ogasawara M, Kim SC, Adamik R, et al. (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5): 3221–30. doi:10.1074/jbc.275.5.3221. PMID 10652308.
• Nevrivy DJ, Peterson VJ, Avram D, et al. (2000). "Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors". J. Biol. Chem. 275 (22): 16827–36. doi:10.1074/jbc.275.22.16827. PMID 10828067.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Poirier MB, Hamann G, Domingue ME, et al. (2005). "General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding". Mol. Endocrinol. 19 (8): 1991–2005. doi:10.1210/me.2004-0449. PMID 15878955.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.