In molecular biology, the chromo shadow ___domain is a protein ___domain which is distantly related to the chromodomain. It is always found in association with a chromodomain.[1] Proteins containing a chromo shadow ___domain include Drosophila and human heterochromatin protein Su(var)205 (HP1); and mammalian modifier 1 and modifier 2.
| Chromo shadow ___domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 hp1 chromo shadow ___domain in complex with pxvxl motif of caf-1 | |||||||||
| Identifiers | |||||||||
| Symbol | Chromo_shadow | ||||||||
| Pfam | PF01393 | ||||||||
| Pfam clan | CL0049 | ||||||||
| InterPro | IPR008251 | ||||||||
| SCOP2 | 1e0b / SCOPe / SUPFAM | ||||||||
| CDD | cd00034 | ||||||||
| |||||||||
Chromo shadow domains self-aggregate, bringing together the nucleosomes to which their proteins are bound and thus condense the chromatin region they are associated with. Condensed chromatin is not able to be transcribed as the transcription factors and enzymes are not able to access to DNA sequence in this form. Hence chromoshadow ___domain containing proteins repress gene transcription.[2]
References
edit- ^ Aasland R, Stewart AF (August 1995). "The chromo shadow ___domain, a second chromo ___domain in heterochromatin-binding protein 1, HP1". Nucleic Acids Research. 23 (16): 3168–73. doi:10.1093/nar/23.16.3168. PMC 307174. PMID 7667093.
- ^ Yamamoto K, Sonoda M (February 2003). "Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1". Biochemical and Biophysical Research Communications. 301 (2): 287–92. doi:10.1016/S0006-291X(02)03021-8. PMID 12565857.
External links
edit- Eukaryotic Linear Motif resource motif class LIG_HP1_1