Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural ___domain of about 120 residues. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a ___domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this ___domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding ___domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the ___domain. The cGPK's are single chain enzymes that include the two copies of the ___domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this ___domain. Two such cations channels have been fully characterized, one is found in rod cells where it plays a role in visual signal transduction.
| Cyclic nucleotide-binding ___domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of a CAP-DNA complex.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | cNMP_binding | ||||||||||
| Pfam | PF00027 | ||||||||||
| InterPro | IPR000595 | ||||||||||
| SMART | SM00100 | ||||||||||
| PROSITE | PDOC00691 | ||||||||||
| SCOP2 | 1cgp / SCOPe / SUPFAM | ||||||||||
| CDD | cd00038 | ||||||||||
| |||||||||||
Human proteins containing this ___domain
editCNBD1; CNGA1; CNGA2; CNGA3; CNGB1; CNGB3; HCN1; HCN2; HCN3; HCN4; KCNH1; KCNH2; KCNH3; KCNH4; KCNH5; KCNH6; KCNH7; KCNH8; PNPLA6; PNPLA7; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKG1; PRKG2; RAPGEF2; RAPGEF3; RAPGEF4; RAPGEF6; RCNC2; SLC9A10; SLC9A11;
References
edit- ^ Schultz SC, Shields GC, Steitz TA (August 1991). "Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees". Science. 253 (5023): 1001–7. Bibcode:1991Sci...253.1001S. doi:10.1126/science.1653449. PMID 1653449. S2CID 19723922. Archived from the original on 2024-05-02. Retrieved 2020-09-11.
Further reading
edit- Yau, K. W. (1994). "Cyclic nucleotide-gated channels: An expanding new family of ion channels". Proceedings of the National Academy of Sciences of the United States of America. 91 (9): 3481–3483. Bibcode:1994PNAS...91.3481Y. doi:10.1073/pnas.91.9.3481. PMC 43603. PMID 7513422.