Cytoprotection refers to the process by which certain pharmacological agents protect cells, particularly the gastric and intestinal mucosal cells, from injury caused by harmful substances, without inhibiting or neutralizing gastric acid.[1][2]
Gastric
editA gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increased mucus and bicarbonate secretion, enhancement of mucosal blood flow, cellular repair, and antioxidant activity.[3] Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury.[4] Gastric cytoprotective drugs include carbenoxolone, deglycyrrhizinised liquorice, sucralfate (aluminium hydroxide and sulphated sucrose), misoprostol (a prostaglandin analogue), bismuth citrate and zinc L-carnosine.
References
edit- ^ "MeSH Heading: Cytoprotection". Medical Subject Headings. United States National Library of Medicine.
- ^ Rheem HB, Kim N, Nguyen DT, Baskoro GA, Roh JH, Lee JK, et al. (2025-05-22). "Single-Cell Nanoencapsulation: Chemical Synthesis of Artificial Cell-in-Shell Spores". Chemical Reviews. 125 (13): 6366–6396. doi:10.1021/acs.chemrev.4c00984. ISSN 0009-2665. PMID 40403226.
- ^ Szabo S (December 2014). ""Gastric cytoprotection" is still relevant". Journal of Gastroenterology and Hepatology. 29 (Suppl 4): 124–32. doi:10.1111/jgh.12735. PMID 25521744.
- ^ JL W (September 1992). "Prostaglandins, NSAIDs, and cytoprotection". Gastroenterology Clinics of North America. 21 (3): 631–641. doi:10.1016/S0889-8553(21)00052-2. PMID 1516961.
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