FF domains are short protein domains of about 50 amino acids. The ___domain was discovered by multiple sequence alignments. FF domains have been found in various transcription factors, splicing proteins, and signaling proteins. FF domains and WW domains often occur together in proteins.[1]
| Domain found in FBP11, CA150, and PRP40 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystal structure of the TCERG1 FF4-6 tandem repeat ___domain | |||||||||
| Identifiers | |||||||||
| Symbol | FF | ||||||||
| Pfam | PF01846 | ||||||||
| InterPro | IPR002713 | ||||||||
| |||||||||
The structure of the FF ___domain in CA150 (TCERG1) was solved in 2009[2] with refinements in 2013.[3]
FF domains are protein interaction domains and thus can mediate the interaction among different proteins, such as various splicing proteins in the spliceosome. For instance, the interaction of yeast splicing proteins Prp40 and Luc7 is mediated by FF domains.[4]
References
edit- ^ Bedford, M. T.; Leder, P. (July 1999). "The FF ___domain: a novel motif that often accompanies WW domains". Trends in Biochemical Sciences. 24 (7): 264–265. doi:10.1016/s0968-0004(99)01417-6. ISSN 0968-0004. PMID 10390614.
- ^ Lu, Ming; Yang, Jun; Ren, Zhiyong; Sabui, Subir; Espejo, Alexsandra; Bedford, Mark T.; Jacobson, Raymond H.; Jeruzalmi, David; McMurray, John S.; Chen, Xiaomin (2009-10-23). "Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150". Journal of Molecular Biology. 393 (2): 397–408. doi:10.1016/j.jmb.2009.07.086. ISSN 1089-8638. PMC 3319151. PMID 19660470.
- ^ Liu, Jiangxin; Fan, Shilong; Lee, Chul-Jin; Greenleaf, Arno L.; Zhou, Pei (April 2013). "Specific Interaction of the Transcription Elongation Regulator TCERG1 with RNA Polymerase II Requires Simultaneous Phosphorylation at Ser2, Ser5, and Ser7 within the Carboxyl-terminal Domain Repeat". Journal of Biological Chemistry. 288 (15): 10890–10901. doi:10.1074/jbc.M113.460238. PMC 3624469. PMID 23436654.
- ^ Ester, Claudia; Uetz, Peter (2008). "The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71". BMC Biochemistry. 9 (1): 29. doi:10.1186/1471-2091-9-29. ISSN 1471-2091. PMC 2613882. PMID 19014439.
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