FNBP4

Formin-binding protein 4 is a protein that in humans is encoded by the FNBP4 gene.^[5][6]

FNBP4
Identifiers
Aliases	FNBP4, FBP30, formin binding protein 4
External IDs	OMIM: 615265; MGI: 1860513; HomoloGene: 9087; GeneCards: FNBP4; OMA:FNBP4 - orthologs
Gene ___location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 47,716,494 bp[1] End 47,767,443 bp[1]
Gene ___location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 90,745,370 bp[2] End 90,781,021 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa Achilles tendon left ovary body of uterus right ovary canal of the cervix body of pancreas right uterine tube left lobe of thyroid gland Top expressed in tail of embryo neural layer of retina genital tubercle spermatocyte ventricular zone zygote granulocyte cerebellar cortex thymus neural tube More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23360 55935 Ensembl ENSG00000109920 ENSG00000285182 ENSMUSG00000008200 UniProt Q8N3X1 Q6ZQ03 RefSeq (mRNA) NM_015308 NM_001318339 NM_018828 RefSeq (protein) NP_001305268 NP_056123 NP_061298 Location (UCSC) Chr 11: 47.72 – 47.77 Mb Chr 2: 90.75 – 90.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mutations in this gene have been found associated to cases similar to microphthalmia with limb anomalies (doi: 10.1002/ajmg.a.35983).

References

1. ENSG00000285182 GRCh38: Ensembl release 89: ENSG00000109920, ENSG00000285182 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008200 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
6. "Entrez Gene: FNBP4 formin binding protein 4".

Further reading

• Bedford MT, Sarbassova D, Xu J, et al. (2000). "A novel pro-Arg motif recognized by WW domains". J. Biol. Chem. 275 (14): 10359–69. doi:10.1074/jbc.275.14.10359. PMID 10744724.
• Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
• Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of ___domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.