MSRB2

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.^[5][6][7] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

MSRB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L1U
Identifiers
Aliases	MSRB2, CBS-1, CBS1, MSRB, PILB, CGI-131, methionine sulfoxide reductase B2
External IDs	OMIM: 613782; MGI: 1923717; HomoloGene: 56555; GeneCards: MSRB2; OMA:MSRB2 - orthologs
Gene ___location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.2 Start 23,095,579 bp[1] End 23,122,013 bp[1]
Gene ___location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 19,376,251 bp[2] End 19,399,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle apex of heart vena cava left ventricle right auricle of heart Skeletal muscle tissue of rectus abdominis muscle of arm biceps brachii triceps brachii muscle Skeletal muscle tissue of biceps brachii Top expressed in interventricular septum myocardium of ventricle right kidney cardiac muscles granulocyte right ventricle lumbar spinal ganglion proximal tubule cervix skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor oxidoreductase activity actin binding zinc ion binding metal ion binding peptide-methionine (R)-S-oxide reductase activity L-methionine-(R)-S-oxide reductase activity Cellular component cytosol mitochondrion Biological process actin filament polymerization response to oxidative stress protein repair regulation of transcription, DNA-templated cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22921 76467 Ensembl ENSG00000148450 ENSMUSG00000023094 UniProt Q9Y3D2 Q78J03 RefSeq (mRNA) NM_012228 NM_029619 RefSeq (protein) NP_036360 NP_083895 Location (UCSC) Chr 10: 23.1 – 23.12 Mb Chr 2: 19.38 – 19.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• MSRA (gene)
• Methionine oxidation
• SEPX1

References

1. GRCh38: Ensembl release 89: ENSG00000148450 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023094 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.
6. Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.
7. "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

Further reading

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Jung S, Hansel A, Kasperczyk H, et al. (2002). "Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1". FEBS Lett. 527 (1–3): 91–4. doi:10.1016/S0014-5793(02)03171-X. PMID 12220640. S2CID 2170229.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
• Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1–3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519. S2CID 32573388.
• Hansel A, Jung S, Hoshi T, Heinemann SH (2004). "A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1". Redox Rep. 8 (6): 384–8. doi:10.1179/135100003225003429. PMID 14980072.
• Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.