RCOR2

REST corepressor 2 also known as CoREST2 is a protein that in humans is encoded by the RCOR2 gene.^[5]

RCOR2
Identifiers
Aliases	RCOR2, REST corepressor 2
External IDs	OMIM: 616019; MGI: 1859854; HomoloGene: 14280; GeneCards: RCOR2; OMA:RCOR2 - orthologs
Gene ___location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 63,911,230 bp[1] End 63,917,164 bp[1]
Gene ___location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 7,244,690 bp[2] End 7,252,590 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence pancreatic ductal cell ventricular zone vena cava right ventricle pericardium superior surface of tongue pons inferior ganglion of vagus nerve mucosa of pharynx Top expressed in ventricular zone epiblast somite membranous bone tail of embryo ganglionic eminence Dermatocranium mandible otic vesicle maxilla More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding transcription factor binding DNA-binding transcription factor activity transcription corepressor activity enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific protein binding Cellular component transcription repressor complex nucleus transcription regulator complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283248 104383 Ensembl ENSG00000167771 ENSMUSG00000024968 UniProt Q8IZ40 Q8C796 RefSeq (mRNA) NM_173587 NM_001363648 NM_054048 NM_001320554 RefSeq (protein) NP_775858 NP_001350577 NP_001307483 NP_473389 Location (UCSC) Chr 11: 63.91 – 63.92 Mb Chr 19: 7.24 – 7.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CoREST2 is a transcriptional corepressor protein that plays a pivotal role in regulating gene expression critical for stem cell pluripotency,^[6] neurogenesis,^[7] and cell fate determination. Predominantly expressed in embryonic stem cells and the central nervous system, RCOR2 partners with key complexes such as LSD1 to modulate chromatin structure and repress target genes, ensuring proper cell proliferation and differentiation.

References

1. GRCh38: Ensembl release 89: ENSG00000167771 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024968 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RCOR2 – REST corepressor 2".
6. Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, et al. (May 2011). "RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency". Stem Cells. 29 (5). Dayton, Ohio: 791–801. doi:10.1002/stem.634. PMID 21433225.
7. Lam XJ, Maniam S, Cheah PS, Ling KH (October 2023). "REST in the Road Map of Brain Development". Cellular and Molecular Neurobiology. 43 (7): 3417–3433. doi:10.1007/s10571-023-01394-w. PMC 11410019. PMID 37517069.