Simphiwe is a South African given name. Notable people with the name include:
- Simphiwe Dana (born 1980), South African singer-songwriter
- Simphiwe Dludlu (born 1987), South African football defender
- Simphiwe Khonco, South African boxer
- Simphiwe Nongqayi (born 1972), South African boxer
- Simphiwe Yiba (born 1992), South African cricketer
| Gender | Unisex |
|---|---|
| Language(s) | Nguni |
| Origin | |
| Word/name | Southern African |
| Other names | |
| Short form(s) | S'phiwe |
| Related names | Refiloe |