In molecular biology, the protein ___domain TCP is actually a family of transcription factors named after: teosinte branched 1 (tb1, Zea mays (Maize)),[1] cycloidea (cyc) (Antirrhinum majus) (Garden snapdragon)[2] and PCF in rice (Oryza sativa).[3]
| TCP | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TCP | ||||||||
| Pfam | PF03634 | ||||||||
| InterPro | IPR005333 | ||||||||
| PROSITE | PDOC00610 | ||||||||
| SCOP2 | 1grl / SCOPe / SUPFAM | ||||||||
| |||||||||
Function
editMembers of the TCP protein ___domain family appear to be involved in cell proliferation. It may also have a role in signalling pathways since it has three phosphorylation sites. The TCP ___domain is necessary for specific binding to promoter elements of the Proliferating cell nuclear antigen (PCNA) gene and also in DNA binding.[2]
Evolution
editThis family of transcription factors are exclusive to vascular plants. They can be divided into two groups, TCP-C and TCP-P, that appear to have separated following an early gene duplication event.[4] This duplication event may have led to functional divergence and it has been proposed that the TCP-P subfamily are transcriptional repressors, while the TPC-C subfamily are transcription activators.[5]
Structure
editThe TCP proteins code for structurally related proteins implicated in the evolution of key morphological traits.[2] However, the biochemical function of CYC and TB1 proteins remains to be demonstrated. One of the conserved regions is predicted to form a non-canonical basic-Helix-Loop-Helix (bHLH) structure. This ___domain is also found in two rice DNA-binding proteins, PCF1 and PCF2, where it has been shown to be involved in DNA-binding and dimerization.
References
edit- ^ Finlayson SA (May 2007). "Arabidopsis Teosinte Branched1-like 1 regulates axillary bud outgrowth and is homologous to monocot Teosinte Branched1". Plant Cell Physiol. 48 (5): 667–77. doi:10.1093/pcp/pcm044. PMID 17452340.
- ^ a b c Cubas P, Lauter N, Doebley J, Coen E (April 1999). "The TCP ___domain: a motif found in proteins regulating plant growth and development". Plant J. 18 (2): 215–22. doi:10.1046/j.1365-313x.1999.00444.x. PMID 10363373.
- ^ Kosugi S, Ohashi Y (May 2002). "DNA binding and dimerization specificity and potential targets for the TCP protein family". Plant J. 30 (3): 337–48. doi:10.1046/j.1365-313x.2002.01294.x. PMID 12000681.
- ^ Navaud O, Dabos P, Carnus E, Tremousaygue D, Hervé C (July 2007). "TCP transcription factors predate the emergence of land plants". J. Mol. Evol. 65 (1): 23–33. Bibcode:2007JMolE..65...23N. doi:10.1007/s00239-006-0174-z. PMID 17568984. S2CID 2961858.
- ^ Li C, Potuschak T, Colón-Carmona A, Gutiérrez RA, Doerner P (September 2005). "Arabidopsis TCP20 links regulation of growth and cell division control pathways". Proc. Natl. Acad. Sci. U.S.A. 102 (36): 12978–83. Bibcode:2005PNAS..10212978L. doi:10.1073/pnas.0504039102. PMC 1200278. PMID 16123132.
External links
edit- TCP family Archived 2013-12-07 at the Wayback Machine at PlantTFDB: Plant Transcription Factor Database